In-vivo X-ray Dark-Field Chest Radiography of a Pig.

Autor: Gromann LB; Chair of Biomedical Physics & Institute of Medical Engineering, Technical University of Munich, 85748, Garching, Germany. lukas.gromann@tum.de., De Marco F; Chair of Biomedical Physics & Institute of Medical Engineering, Technical University of Munich, 85748, Garching, Germany., Willer K; Chair of Biomedical Physics & Institute of Medical Engineering, Technical University of Munich, 85748, Garching, Germany., Noël PB; Chair of Biomedical Physics & Institute of Medical Engineering, Technical University of Munich, 85748, Garching, Germany.; Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, 81675, München, Germany., Scherer K; Chair of Biomedical Physics & Institute of Medical Engineering, Technical University of Munich, 85748, Garching, Germany., Renger B; Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, 81675, München, Germany., Gleich B; Institute of Medical Engineering, Technical University of Munich, 85748, Garching, Germany., Achterhold K; Chair of Biomedical Physics & Institute of Medical Engineering, Technical University of Munich, 85748, Garching, Germany., Fingerle AA; Chair of Biomedical Physics & Institute of Medical Engineering, Technical University of Munich, 85748, Garching, Germany.; Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, 81675, München, Germany., Muenzel D; Chair of Biomedical Physics & Institute of Medical Engineering, Technical University of Munich, 85748, Garching, Germany.; Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, 81675, München, Germany., Auweter S; Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital Munich, 81377, Munich, Germany., Hellbach K; Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital Munich, 81377, Munich, Germany., Reiser M; Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital Munich, 81377, Munich, Germany., Baehr A; Institute of Molecular Animal Breeding and Biotechnology, Ludwig-Maximilian-University, 85764, Oberschleißheim, Germany., Dmochewitz M; Institute of Molecular Animal Breeding and Biotechnology, Ludwig-Maximilian-University, 85764, Oberschleißheim, Germany., Schroeter TJ; Institute of Microstructure Technology, Karlsruhe Institute of Technology, 76344, Eggenstein-Leopoldshafen, Germany., Koch FJ; Institute of Microstructure Technology, Karlsruhe Institute of Technology, 76344, Eggenstein-Leopoldshafen, Germany., Meyer P; Institute of Microstructure Technology, Karlsruhe Institute of Technology, 76344, Eggenstein-Leopoldshafen, Germany., Kunka D; Institute of Microstructure Technology, Karlsruhe Institute of Technology, 76344, Eggenstein-Leopoldshafen, Germany., Mohr J; Institute of Microstructure Technology, Karlsruhe Institute of Technology, 76344, Eggenstein-Leopoldshafen, Germany., Yaroshenko A; Chair of Biomedical Physics & Institute of Medical Engineering, Technical University of Munich, 85748, Garching, Germany.; Philips Medical Systems DMC GmbH, 22335, Hamburg, Germany., Maack HI; Philips Medical Systems DMC GmbH, 22335, Hamburg, Germany., Pralow T; Philips Medical Systems DMC GmbH, 22335, Hamburg, Germany., van der Heijden H; Philips Medical Systems DMC GmbH, 22335, Hamburg, Germany., Proksa R; Philips GmbH Innovative Technologies, Research Laboratories, 22335, Hamburg, Germany., Koehler T; Philips GmbH Innovative Technologies, Research Laboratories, 22335, Hamburg, Germany.; Institute for Advanced Study, Technical University of Munich, 85748, Garching, Germany., Wieberneit N; Philips Medical Systems DMC GmbH, 22335, Hamburg, Germany., Rindt K; Philips Medical Systems DMC GmbH, 22335, Hamburg, Germany., Rummeny EJ; Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, 81675, München, Germany., Pfeiffer F; Chair of Biomedical Physics & Institute of Medical Engineering, Technical University of Munich, 85748, Garching, Germany.; Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, 81675, München, Germany.; Institute for Advanced Study, Technical University of Munich, 85748, Garching, Germany., Herzen J; Chair of Biomedical Physics & Institute of Medical Engineering, Technical University of Munich, 85748, Garching, Germany. julia.herzen@tum.de.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2017 Jul 06; Vol. 7 (1), pp. 4807. Date of Electronic Publication: 2017 Jul 06.
DOI: 10.1038/s41598-017-05101-w
Abstrakt: X-ray chest radiography is an inexpensive and broadly available tool for initial assessment of the lung in clinical routine, but typically lacks diagnostic sensitivity for detection of pulmonary diseases in their early stages. Recent X-ray dark-field (XDF) imaging studies on mice have shown significant improvements in imaging-based lung diagnostics. Especially in the case of early diagnosis of chronic obstructive pulmonary disease (COPD), XDF imaging clearly outperforms conventional radiography. However, a translation of this technique towards the investigation of larger mammals and finally humans has not yet been achieved. In this letter, we present the first in-vivo XDF full-field chest radiographs (32 × 35 cm 2 ) of a living pig, acquired with clinically compatible parameters (40 s scan time, approx. 80 µSv dose). For imaging, we developed a novel high-energy XDF system that overcomes the limitations of currently established setups. Our XDF radiographs yield sufficiently high image quality to enable radiographic evaluation of the lungs. We consider this a milestone in the bench-to-bedside translation of XDF imaging and expect XDF imaging to become an invaluable tool in clinical practice, both as a general chest X-ray modality and as a dedicated tool for high-risk patients affected by smoking, industrial work and indoor cooking.
Databáze: MEDLINE