Exercise improves cytokine profile in HIV-infected people: A randomized clinical trial.

Autor: Pedro RE; Department of Physical Education, State University of Maringá, Maringá, Brazil., Candido N; Department of Physical Education, State University of Maringá, Maringá, Brazil., Guariglia DA; Department of Physical Education, Estácio de Sá University, Ourinhos, Brazil., Melo BP; Exercise Physiology Laboratory, EEFFTO, Federal University of Minas Gerais, Belo Horizonte, Brazil., Bertolini DA; Department of Clinical and Biomedical Analysis, State University of Maringá, Maringá, Brazil., Peres SB; Department of Physiological Sciences, State University of Maringá, Maringá, Brazil., Franzói de Moraes SM; Department of Physiological Sciences, State University of Maringá, Maringá, Brazil. Electronic address: smfmoraes@gmail.com.
Jazyk: angličtina
Zdroj: Cytokine [Cytokine] 2017 Nov; Vol. 99, pp. 18-23. Date of Electronic Publication: 2017 Jul 03.
DOI: 10.1016/j.cyto.2017.06.019
Abstrakt: Purpose: Verify the effects of concurrent training on cytokines in people living with HIV under antiretroviral therapy (ART) treatment.
Methods: This was a blinded, parallel-group, clinical trial, where 49 participants, divided in two groups, either control group or concurrent training group, took part in the intervention. The control group performed recreational activities and concurrent training group participated of 16-week, 3 times per week of heart rate guided-aerobic plus resistance training for major muscular groups. Cytokines (interleukins 4, 5, 6, 8, 10, tumor necrosis factor-α, interferon-γ, and granulocyte-macrophage colony-stimulating factor) were measured before and after 16-week experimental period using flow cytometry.
Results: From 49 participants who took part in the intervention, 28 completed the program and had data analyzed. There was a significant interaction for IL-8, which increased for control group: 7.1±5.1 vs. 8.1±6.0 and a decrease for concurrent training: 8.0±4.4 vs. 5.4±2.3. In addition, magnitude-based inference showed a likely beneficial effect for the training group when compared to the control group for IL-8, IL-5, and IL-10. The difference perceptual: mean and [CI 90%] between delta of difference within groups was -43.1 [-64.0 to -10.0] and -6.6 [-14.7 to 2.3], respectively.
Conclusion: Short-term exercise is able to decrease the levels of IL-5, IL-8, and IL-10 in HIV-infected people undergoing ART.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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