| Autor: |
Siewert B; Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 233CC Leiden, The Netherlands. bonnet@chem.leidenuniv.nl., Langerman M, Hontani Y, Kennis JTM, van Rixel VHS, Limburg B, Siegler MA, Talens Saez V, Kieltyka RE, Bonnet S |
| Jazyk: |
angličtina |
| Zdroj: |
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2017 Oct 10; Vol. 53 (81), pp. 11126-11129. |
| DOI: |
10.1039/c7cc02989f |
| Abstrakt: |
Coupling the notoriously non-emissive complex [Ru(tpy)(bpy)Cl]Cl (tpy = 2,2':6',2''-terpyridine, bpy = 2,2'-bipyridine) to a C 12 alkyl chain via an amide linker on the 4' position of the terpyridine yielded a new amphiphilic ruthenium complex showing red emission and chloride-dependent aggregation properties. This emissive complex is highly cytotoxic in A549 non-small lung cancer cells where it can be followed by confocal microscopy. Uptake occurs within minutes, first by insertion into the cellular membrane, and then by migration to the peri-nuclear region. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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