| Autor: |
Lemes SR; Laboratório de Estudos Experimentais e Biotecnológicos, Pontifícia Universidade Católica de Goiás/PUC, Rua 232, 128, 3º andar, Sala 5, 74605-010 Goiânia, GO, Brazil., Chaves DA; Laboratório de Estudos Experimentais e Biotecnológicos, Pontifícia Universidade Católica de Goiás/PUC, Rua 232, 128, 3º andar, Sala 5, 74605-010 Goiânia, GO, Brazil., Silva NJD Júnior; Laboratório de Estudos Experimentais e Biotecnológicos, Pontifícia Universidade Católica de Goiás/PUC, Rua 232, 128, 3º andar, Sala 5, 74605-010 Goiânia, GO, Brazil., Carneiro CC; Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Goiás/UFG, Campus-II, Avenida Esperança, s/n, Campus Samambaia, 74690-900 Goiânia, GO, Brazil., Chen-Chen L; Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Goiás/UFG, Campus-II, Avenida Esperança, s/n, Campus Samambaia, 74690-900 Goiânia, GO, Brazil., Almeida LM; Laboratório de Biotecnologia, Universidade Estadual de Goiás/UEG, Unidade Universitária de Ciências Exatas e Tecnológicas, Caixa Postal 459, 75132-903 Anápolis, GO, Brazil., Gonçalves PJ; Instituto de Física, Universidade Federal de Goiás/UFG, Campus-II, Avenida Esperança, s/n, Campus Samambaia, 74690-900 Goiânia, GO, Brazil., Melo-Reis PR; Laboratório de Estudos Experimentais e Biotecnológicos, Pontifícia Universidade Católica de Goiás/PUC, Rua 232, 128, 3º andar, Sala 5, 74605-010 Goiânia, GO, Brazil. |
| Abstrakt: |
The aim of this study was to evaluate the possible protective of C. guianensis oil against MMC and CP, which are direct- and indirect-acting chemical mutagens, using the micronucleus test. Three experiments were performed. First the C. guianensis oil was co-administered to mice at doses of 250, 500 and 1000 mg/kg bw with 4 mg/kg bw MMC or 50 mg/kg bw CP. Second, the mutagenic drug (CP) was administered ip 50 mg/kg bw and after 6 and 12 hours 250 and 500 mg/kg bw of C. guianensis oil were administered. In the last, C. guianensis oil was administrated (250 and 500 mg/kg bw) during five days and after it was administered ip 50 mg/kg bw CP. The results obtained showed that the C. guianensis oil is not cytotoxic neither genotoxic to mouse bone marrow. Regarding the antimutagenic effect, all doses of C. guianensis oil were significantly (p < 0.05) effective in reducing the frequency of micronucleated polychromatic erythrocytes, when compared with MMC or CP alone. Based on these results, our results suggest that the C. guianensis oil shows medicinal potential as an antimutagenic agent, modulating the mutagenicity caused by both direct- and indirect-acting chemical mutagens, in a mammalian model. |
