Cypermethrin inhibits interleukin-6-induced androgen receptor transactivation through signal transducer and activator of transcription 3.

Autor: Zhou JL; a School of Public Health , Xuzhou Medical University, Xuzhou , PR China., Ding Z; a School of Public Health , Xuzhou Medical University, Xuzhou , PR China., Ge X; a School of Public Health , Xuzhou Medical University, Xuzhou , PR China., Shi QM; a School of Public Health , Xuzhou Medical University, Xuzhou , PR China., Wang HX; a School of Public Health , Xuzhou Medical University, Xuzhou , PR China., Chen G; a School of Public Health , Xuzhou Medical University, Xuzhou , PR China., Li MX; a School of Public Health , Xuzhou Medical University, Xuzhou , PR China., Wang H; a School of Public Health , Xuzhou Medical University, Xuzhou , PR China., Ju Q; a School of Public Health , Xuzhou Medical University, Xuzhou , PR China., Wang Q; a School of Public Health , Xuzhou Medical University, Xuzhou , PR China., Zhang JP; a School of Public Health , Xuzhou Medical University, Xuzhou , PR China., Zhang MR; a School of Public Health , Xuzhou Medical University, Xuzhou , PR China., Xu LC; a School of Public Health , Xuzhou Medical University, Xuzhou , PR China.
Jazyk: angličtina
Zdroj: Toxicology mechanisms and methods [Toxicol Mech Methods] 2017 Nov; Vol. 27 (9), pp. 717-722. Date of Electronic Publication: 2017 Jul 18.
DOI: 10.1080/15376516.2017.1351505
Abstrakt: The insecticide cypermethrin has been considered as an endocrine-disrupting chemicals (EDCs) with anti-androgenic activity by interfering with interleukin-6 (IL-6) - induced ligand-independent AR signaling. The purpose of this study was to clarify whether the signal transducer and activator of transcription 3 (STAT3) was involved in the antagonism effect of cypermethrin. In this study, the Western blot was to test the level of STAT3 phosphorylation and the mammalian two-hybrid assay was developed to assess the AR-STAT3 interaction. The date showed that IL-6 increased the phosphorylation level of STAT3 and enhanced the AR-STAT3 interaction. Cypermethrin did not affect the phosphorylation level of STAT3 induced by IL-6, while suppressed the AR-STAT3 interaction induced by IL-6 significantly at the concentration of 10 -5  M (p < 0.05). The study indicates cypermethrin inhibits IL-6-induced AR signaling by suppressing the interaction between the AR and STAT3. We provide a novel mechanism of cypermethrin-mediated antagonism on IL-6-induced AR activation associated with STAT3.
Databáze: MEDLINE
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