| Autor: |
Hawas UW; a Faculty of Marine Sciences, Marine Chemistry Department , King Abdulaziz University , Jeddah , Saudi Arabia.; b Phytochemistry and Plant Systematic Department , National Research Centre , Cairo , Egypt., Abou El-Kassem LT; c Pharmacognosy Department , National Research Centre , Cairo , Egypt., Abdelfattah MS; d Faculty of Science, Marine Natural Products Research Unit , Helwan University , Cairo , Egypt., Elmallah MIY; d Faculty of Science, Marine Natural Products Research Unit , Helwan University , Cairo , Egypt., Eid MAG; d Faculty of Science, Marine Natural Products Research Unit , Helwan University , Cairo , Egypt., Monier M; c Pharmacognosy Department , National Research Centre , Cairo , Egypt., Marimuthu N; e Faculty of Marine Sciences, Marine Biology Department , King Abdul Aziz University , Jeddah , Saudi Arabia.; f Zoological Survey of India (Ministry of Environment, Forest and Climate Change, Govt. of India) , FPS Building, Indian Museum Complex, Kolkata , India. |
| Abstrakt: |
The chemical investigation of the methylene chloride fraction of marine sponge Hyrtios erectus led to the isolation of the known oxysterol (2) along with a new alkyl benzoate compound identified by spectroscopic methods (NMR and MS) as 4'-methylheptyl benzoate (1), whilst the n-butanol fraction afforded the known indole 3-carbaldehyde and β-carboline derivatives. Moreover, the hexane fraction was analysed by GC-MS for their fatty acids (FAs). A total of 17 FAs with chain lengths between 14 and 25 carbons were identified. Methyl-branched FAs are predominated suggesting the presence of bacterial symbionts in the H. erectus sponge. Furthermore, compounds 1 and 2 displayed significant cytotoxicity against breast adenocarcinoma (MCF-7) with IC 50 values of 2.4 and 3.8 μM, respectively, since compound 2 was also shown to have potent cytotoxic effect against hepatocellular carcinoma cells (HepG 2) with IC 50 value of 1.3 μM. |
