Genetic variants and risk of asthma in an American Indian population.

Autor:	Best LG; Missouri Breaks Industries Research Inc, Eagle Butte, South Dakota; Science Department, Turtle Mountain Community College, Belcourt, North Dakota; School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota. Electronic address: lbest@restel.com., Azure C; Science Department, Turtle Mountain Community College, Belcourt, North Dakota., Segarra A; Science Department, Turtle Mountain Community College, Belcourt, North Dakota., Enright KJ; Missouri Breaks Industries Research Inc, Eagle Butte, South Dakota., Hamley S; Science Department, Turtle Mountain Community College, Belcourt, North Dakota., Jerome D; Science Department, Turtle Mountain Community College, Belcourt, North Dakota., O'Leary MA; Missouri Breaks Industries Research Inc, Eagle Butte, South Dakota., O'Leary RA; Missouri Breaks Industries Research Inc, Eagle Butte, South Dakota., Parisien A; Science Department, Turtle Mountain Community College, Belcourt, North Dakota., Trottier K; Science Department, Turtle Mountain Community College, Belcourt, North Dakota., Yracheta JM; Missouri Breaks Industries Research Inc, Eagle Butte, South Dakota., Torgerson DG; Department of Medicine, University of California, San Francisco, San Francisco, California.
Jazyk:	angličtina
Zdroj:	Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology [Ann Allergy Asthma Immunol] 2017 Jul; Vol. 119 (1), pp. 31-36.e1.
DOI:	10.1016/j.anai.2017.05.015
Abstrakt:	Background: Asthma is recognized as a complex, multifactorial disease with a genetic component that is well recognized. Certain genetic variants are associated with asthma in a number of populations. Objective: To determine whether the same variants increase the risk of asthma among American Indian children. Methods: The electronic medical records of an Indian Health Service facility identified all children between 6 and 17 years of age with case-defining criteria for asthma (n = 108). Control children (n = 216), matched for age, were also identified. Real-time polymerase chain reaction assays were used to genotype 10 single-nucleotide polymorphisms (SNPs) at 6 genetic loci. Genotypic distributions among cases and controls were evaluated by χ 2 and logistic regression methods. Results: A variant at 5q22.1 revealed a statistically significant imbalance in the distribution of genotypes between case-control pairs (rs10056340, P < .001). In logistic regression analyses, the same variant at 5q22.1 and a variant at 17q21 were associated with asthma at P < .05 (rs10056340 and rs9303277). Inclusions of age, body mass index, and atopy in multivariate models revealed significant associations between rs10056340 (odds ratio, 2.020; 95% confidence interval, 1.283-3.180; P = .002) and all 5 17q21 SNPs and asthma in this population. In analyses restricted to atopic individuals, the association of rs10056340 was essentially unchanged, whereas among nonatopic individuals the trend was in the same direction but nonsignificant. The reverse was true for the 17q21 SNPs. Conclusion: These findings demonstrate that many variants commonly associated with asthma in other populations also accompany this condition among American Indian children. American Indian children also appear to have an increased risk of asthma associated with obesity. (Copyright © 2017 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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