| Autor: |
Weng WC; Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.; Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Pediatric Neurology, National Taiwan University Children's Hospital, Taipei, Taiwan., Tsui PH; Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan., Lin CW; Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan., Lu CH; Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Lin CY; Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.; Department of Pediatrics, Yong-He Cardinal Tien Hospital, Taipei, Taiwan., Shieh JY; Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan., Lu FL; Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.; Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Pediatric Neurology, National Taiwan University Children's Hospital, Taipei, Taiwan., Ee TW; Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Wu KW; Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan., Lee WT; Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan. leeped@hotmail.com.; Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan. leeped@hotmail.com.; Department of Pediatric Neurology, National Taiwan University Children's Hospital, Taipei, Taiwan. leeped@hotmail.com.; Graduate Institute of Brain and Mind Sciences, National Taiwan University, Taipei, Taiwan. leeped@hotmail.com. |
| Abstrakt: |
Duchenne muscular dystrophy (DMD) is the most common debilitating muscular disorder. Developing a noninvasive measure for monitoring the progression of this disease is critical. The present study tested the effectiveness of using ultrasound Nakagami imaging to evaluate the severity of the dystrophic process. A total of 47 participants (40 with DMD and 7 healthy controls) were recruited. Patients were classified into stage 1 (presymptomatic and ambulatory), stage 2 (early nonambulatory), and stage 3 (late nonambulatory). All participants underwent ultrasound examinations on the rectus femoris, tibialis anterior, and gastrocnemius. The results revealed that the ultrasound Nakagami parameter correlated positively with functional severity in the patients with DMD. The median Nakagami parameter of the gastrocnemius muscle increased from 0.50 to 0.85, corresponding to the largest dynamic range between normal and stage 3. The accuracy, sensitivity, and specificity of diagnosing walking function were 85.52%, 76.31%, and 94.73%, respectively. The Nakagami parameter of the rectus femoris and gastrocnemius muscles correlated negatively with the 6-minute walking distance in the ambulatory patients. Therefore, changes in the Nakagami parameter for the gastrocnemius muscle are suitable for monitoring disease progression in ambulatory patients and for predicting ambulation loss. Ultrasound Nakagami imaging shows potential for evaluating patients with DMD. |
