Cerebral hyperperfusion on arterial spin labeling MRI after reperfusion therapy is related to hemorrhagic transformation.

Autor: Okazaki S; 1 Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan.; 2 Department of Data Science, Research and Development Initiative Center, National Cerebral and Cardiovascular Center, Suita, Japan., Yamagami H; 1 Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan., Yoshimoto T; 1 Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan., Morita Y; 3 Department of Radiology, National Cerebral and Cardiovascular Center, Suita, Japan., Yamamoto H; 2 Department of Data Science, Research and Development Initiative Center, National Cerebral and Cardiovascular Center, Suita, Japan., Toyoda K; 4 Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan., Ihara M; 1 Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan.
Jazyk: angličtina
Zdroj: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2017 Sep; Vol. 37 (9), pp. 3087-3090. Date of Electronic Publication: 2017 Jun 30.
DOI: 10.1177/0271678X17718099
Abstrakt: Early detection of hemorrhagic transformation after reperfusion therapy is crucial in acute stroke treatment. Here, we evaluated the relationship between hemorrhagic transformation and post-reperfusion hyperperfusion using pulsed arterial spin labeling (ASL) perfusion MRI and 123 I-iodoamphetamine single-photon emission-computed tomography. Patients who developed hemorrhagic transformation showed significantly higher cerebral blood flow in the affected lesion after thrombolysis and/or endovascular intervention. Focal hyperperfusion (ipsilateral to contralateral ratio >1.5) was associated with hemorrhagic transformation after reperfusion (odds ratio, 9.3; 95% confidence interval, 1.4-64.0). Our findings suggest that post-reperfusion hyperperfusion on ASL could represent a reliable marker of hemorrhagic transformation.
Databáze: MEDLINE
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