Corticosterone influences gerbil (Meriones unguiculatus) prostatic morphophysiology and alters its proliferation and apoptosis rates.

Autor: Antoniassi JQ; Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), São Paulo, Brazil., Fochi RA; Department of Biology, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), University Estadual Paulista (UNESP), São Paulo, Brazil., Góes RM; Department of Biology, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), University Estadual Paulista (UNESP), São Paulo, Brazil., Vilamaior PSL; Department of Biology, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), University Estadual Paulista (UNESP), São Paulo, Brazil., Taboga SR; Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), São Paulo, Brazil.; Department of Biology, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), University Estadual Paulista (UNESP), São Paulo, Brazil.
Jazyk: angličtina
Zdroj: International journal of experimental pathology [Int J Exp Pathol] 2017 Jun; Vol. 98 (3), pp. 134-146. Date of Electronic Publication: 2017 Jun 29.
DOI: 10.1111/iep.12232
Abstrakt: Glucocorticoids (GCs) are hormones that are widely used in medicine; but although side effects are generally recognised, little is known about the precise mechanisms that is implicated in many of these side effects. Furthermore, GCs are highly correlated with stress and behaviour disorders. This study evaluated the effects of the glucocorticoid corticosterone on the ventral prostate of the Mongolian gerbil. Male gerbils (Meriones unguiculatus) (n = 5) received intraperitoneal injections of saline or corticosterone in doses of 0.5 mg/kg/day and 1.5 mg/kg/day for 5 days; while some of the animals were killed immediately after the treatment, the others were killed 5 days after the treatment period. The data show that corticosterone influences the structure and functionality of this organ. This hormone has anti-proliferative and anti-apoptotic properties in the prostate. In addition, the frequencies of the androgen (AR), oestrogen (ERα, ERβ) and glucocorticoid (GR) receptors changed. The frequencies of AR, GR and ERβ decreased in the Ct1/5 group; in the groups with rest period, the frequencies of GR increased and ERβ decreased in the epithelium. Changes in the proliferative index, apoptotic index and receptor activity may have contributed to the emergence of prostatic morphological alterations, such as the presence of cellular debris and inflammatory cells. Different doses of corticosterone had variable effects on the prostate, with a higher dose showing subtler effects and a lower dose showing more striking effects. The corticosterone effects on nuclear receptors were reverted or attenuated after a rest period, which was not observed for proliferation and apoptosis. In summary, we have demonstrated that corticosterone might influence the prostatic morphophysiology and that these changes may be linked in some way to the altered receptor distribution.
(© 2017 The Authors. International Journal of Experimental Pathology © 2017 International Journal of Experimental Pathology.)
Databáze: MEDLINE
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