Population-based Semen Analysis Results and Fertility Among Patients With Inflammatory Bowel Disease: Results From Subfertility Health Assisted Reproduction and the Environment (SHARE) Study.

Autor: Martin L; Department of Surgery, University of Utah Health Sciences Center, Salt Lake City, UT. Electronic address: luke.martin@hsc.utah.edu., Mullaney S; Division of Urology, University of Utah Health Sciences Center, Salt Lake City, UT., Peche W; Department of Surgery, University of Utah Health Sciences Center, Salt Lake City, UT., Peterson K; Division of Gastroenterology, University of Utah Health Sciences Center, Salt Lake City, UT., Chan S; Division of Gastroenterology, University of Utah Health Sciences Center, Salt Lake City, UT., Morton R; Division of Gastroenterology, University of Utah Health Sciences Center, Salt Lake City, UT., Wan Y; Utah Population Database, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT., Zhang C; Division of Epidemiology, University of Utah Health Sciences Center, Salt Lake City, UT., Presson AP; Division of Epidemiology, University of Utah Health Sciences Center, Salt Lake City, UT., Emery B; Division of Urology, University of Utah Health Sciences Center, Salt Lake City, UT., Aston K; Division of Urology, University of Utah Health Sciences Center, Salt Lake City, UT., Jenkins T; Division of Urology, University of Utah Health Sciences Center, Salt Lake City, UT., Carrell D; Division of Urology, University of Utah Health Sciences Center, Salt Lake City, UT., Hotaling J; Division of Urology, University of Utah Health Sciences Center, Salt Lake City, UT.
Jazyk: angličtina
Zdroj: Urology [Urology] 2017 Sep; Vol. 107, pp. 114-119. Date of Electronic Publication: 2017 Jun 27.
DOI: 10.1016/j.urology.2017.06.029
Abstrakt: Objective: To evaluate male fertility in Crohn disease (CD) and ulcerative colitis (UC) by examining semen analysis results and paternity from the SHARE study (Subfertility Health Assisted Reproduction and the Environment), a population-based cohort of semen analysis results from Utah men.
Methods: A population-based cohort of men with CD or UC was identified using the Utah Population Database (contains person-level linked demographic, genealogical, and medical record information for 85% of Utahans) from 1996 to 2014, and validated by clinical chart review. This cohort was then cross-linked (n = 55) to the SHARE population dataset of semen analysis results. Men with CD or UC were compared with population-based, age-matched, paired (1:1) controls (n = 47). Paternity was evaluated though presence and number of linked offspring and inter-birth interval.
Results: Offspring were identified in 71% of UC patients (mean of 1.8 children) and 61% of CD patients (mean of 1.2 children). Compared with matched controls, there were no differences in number of offspring, mean inter-birth interval, or any of the evaluated semen analysis parameters among either men with CD or UC.
Conclusion: Fertility and semen analysis values among men with UC or CD are not significantly impacted compared with population-based, age-matched controls.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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