Effect of dietary consumption as a modifier on the association between FTO gene variants and excess body weight in children from an admixed population in Brazil: the Social Changes, Asthma and Allergy in Latin America (SCAALA) cohort study.

Autor:	Vilella M; 1Departamento Ciência da Nutrição,Escola de Nutrição,Universidade Federal da Bahia- Av,Araújo Pinho, no 32,Canela, CEP: 40.110-150,Salvador,Bahia,Brasil., Nunes de Oliveira Costa G; 2Instituto de Saúde Coletiva,Universidade Federal da Bahia,Rua Basílio da Gama,s/n Campus Universitário Canela, CEP: 40.110-040, Salvador,Bahia,Brasil., Lima Barreto M; 2Instituto de Saúde Coletiva,Universidade Federal da Bahia,Rua Basílio da Gama,s/n Campus Universitário Canela, CEP: 40.110-040, Salvador,Bahia,Brasil., Alexandrina Figueredo C; 4Departamento de Ciências da Biointeração,Instituto de Ciências da Saúde,Universidade Federal da Bahia,AV. Reitor Miguel Calmon. S/N,CEP: 40110-100, Salvador,Bahia,Brasil., Maria Alcantara-Neves N; 5Instituto de Matemática,Universidade Federal da Bahia - Av,Adhemar de Barros,s/n - Ondina, CEP: 40.170-110, Salvador,Bahia,Brasil., Cunha Rodrigues L; 6Department of Epidemiology and Population Health,London School of Hygiene and Tropical Medicine (LSHTM),Keppel Street,London,WC1E 7HT,UK., Maria Alvim de Matos S; 2Instituto de Saúde Coletiva,Universidade Federal da Bahia,Rua Basílio da Gama,s/n Campus Universitário Canela, CEP: 40.110-040, Salvador,Bahia,Brasil., Leovigildo Fiaccone R; 5Instituto de Matemática,Universidade Federal da Bahia - Av,Adhemar de Barros,s/n - Ondina, CEP: 40.170-110, Salvador,Bahia,Brasil., Oliveira P; 2Instituto de Saúde Coletiva,Universidade Federal da Bahia,Rua Basílio da Gama,s/n Campus Universitário Canela, CEP: 40.110-040, Salvador,Bahia,Brasil., Rocha A; 1Departamento Ciência da Nutrição,Escola de Nutrição,Universidade Federal da Bahia- Av,Araújo Pinho, no 32,Canela, CEP: 40.110-150,Salvador,Bahia,Brasil., de Cássia Ribeiro-Silva R; 1Departamento Ciência da Nutrição,Escola de Nutrição,Universidade Federal da Bahia- Av,Araújo Pinho, no 32,Canela, CEP: 40.110-150,Salvador,Bahia,Brasil.
Jazyk:	angličtina
Zdroj:	The British journal of nutrition [Br J Nutr] 2017 Jun; Vol. 117 (11), pp. 1503-1510. Date of Electronic Publication: 2017 Jun 29.
DOI:	10.1017/S0007114517001386
Abstrakt:	Previous studies have shown associations of variants of the FTO gene with body weight, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the north-eastern Brazilian population. This study evaluated the association between SNP in the FTO gene and excess weight in Salvador, Bahia, Brazil. In addition, the effect of diet as a modifier on this association was also investigated. This cross-sectional study included 1191 participants aged 4-11 years, who were genotyped for 400 variants of the FTO gene. Direct anthropometric measures were made and dietary data were obtained by 24-h food recall. Multivariate logistic regression analyses were used to assess the associations of interest. Overall, 11·2 % of the individuals included in the study were overweight/obese. Interactions were identified between the percentage energy intake from proteins and obesity risk linked to the rs62048379 SNP (P interaction=0·01) and also between fat intake (PUFA:SFA ratio) and obesity risk linked to the rs62048379 SNP (P interaction=0·01). The T allele for the variant rs62048379 was positively associated with overweight/obesity in individuals whose percentage energy intake from protein was above the median (OR 2·00; 95 % CI 1·05, 3·82). The rs62048379 SNP was also associated with overweight/obesity in individuals whose PUFA:SFA ratio was below the median (OR 1·63; 95 % CI 1·05, 2·55). The association between FTO gene variants and excess body weight can be modulated by dietary characteristics, particularly by fatty acid distribution and dietary protein intake in children.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu