| Autor: |
Kim Y; Muscle Health Research Centre, York University, Toronto, ON, Canada M3J 1P3.; School of Kinesiology and Health Science, York University, Toronto, ON, Canada M3J 1P3., Triolo M; Muscle Health Research Centre, York University, Toronto, ON, Canada M3J 1P3.; School of Kinesiology and Health Science, York University, Toronto, ON, Canada M3J 1P3., Hood DA; Muscle Health Research Centre, York University, Toronto, ON, Canada M3J 1P3.; School of Kinesiology and Health Science, York University, Toronto, ON, Canada M3J 1P3. |
| Abstrakt: |
Mitochondria are characterized by its pivotal roles in managing energy production, reactive oxygen species, and calcium, whose aging-related structural and functional deteriorations are observed in aging muscle. Although it is still unclear how aging alters mitochondrial quality and quantity in skeletal muscle, dysregulation of mitochondrial biogenesis and dynamic controls has been suggested as key players for that. In this paper, we summarize current understandings on how aging regulates muscle mitochondrial biogenesis, while focusing on transcriptional regulations including PGC-1 α , AMPK, p53, mtDNA, and Tfam. Further, we review current findings on the muscle mitochondrial dynamic systems in aging muscle: fusion/fission, autophagy/mitophagy, and protein import. Next, we also discuss how endurance and resistance exercises impact on the mitochondrial quality controls in aging muscle, suggesting possible effective exercise strategies to improve/maintain mitochondrial health. |
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