| Autor: |
Verstraete M, Bleifeld W, Brower RW, Charbonnier B, Collen D, de Bono DP, Dunning AJ, Lennane RJ, Lubsen J, Mathey DG, et. al. |
| Jazyk: |
angličtina |
| Zdroj: |
Lancet (London, England) [Lancet] 1985 Nov 02; Vol. 2 (8462), pp. 965-9. |
| DOI: |
10.1016/s0140-6736(85)90523-9 |
| Abstrakt: |
In a double-blind randomised trial 129 patients with first myocardial infarction of less than 6 h duration were allocated to treatment with human recombinant tissue-type plasminogen activator (rt-PA) given intravenously over 90 min, or to placebo infusion. Coronary angiography at the end of this infusion showed that the infarct-related vessel was patent in 61% of 62 assessable coronary angiograms in the rt-PA-treated group compared with 21% in the control group. Treatment with rt-PA was not accompanied by any major complications. In the rt-PA group the circulating fibrinogen level at the end of the catheterisation was 52 +/- 29% (mean +/- SD) of the starting value. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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