Cutting Edge: Eosinophils Undergo Caspase-1-Mediated Pyroptosis in Response to Necrotic Liver Cells.

Autor:	Palacios-Macapagal D; MedImmune, Gaithersburg, MD 20878; and., Connor J; MedImmune, Gaithersburg, MD 20878; and., Mustelin T; MedImmune, Gaithersburg, MD 20878; and., Ramalingam TR; National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892., Wynn TA; National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892., Davidson TS; MedImmune, Gaithersburg, MD 20878; and DavidsonT@MedImmune.com.
Jazyk:	angličtina
Zdroj:	Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2017 Aug 01; Vol. 199 (3), pp. 847-853. Date of Electronic Publication: 2017 Jun 26.
DOI:	10.4049/jimmunol.1601162
Abstrakt:	Many chronic liver disorders are characterized by dysregulated immune responses and hepatocyte death. We used an in vivo model to study the immune response to necrotic liver injury and found that necrotic liver cells induced eosinophil recruitment. Necrotic liver induced eosinophil IL-1β and IL-18 secretion, degranulation, and cell death. Caspase-1 inhibitors blocked all of these responses. Caspase-1-mediated cell death with accompanying cytokine release is the hallmark of a novel form of cell death termed pyroptosis. To confirm this response in a disease model, we isolated eosinophils from the livers of Schistosoma mansoni -infected mice. S. mansoni eggs lodge in the hepatic sinusoids of infected mice, resulting in hepatocyte death, inflammation, and progressive liver fibrosis. This response is typified by massive eosinophilia, and we were able to confirm pyroptosis in the infiltrating eosinophils. This demonstrated that pyroptosis is a cellular pathway used by eosinophils in response to large-scale hepatic cell death. (Copyright © 2017 by The American Association of Immunologists, Inc.)
Databáze:	MEDLINE
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