The Esophageal Epithelial Barrier in Health and Disease.

Autor:	Blevins CH; Division of Gastroenterology and Hepatology, Mayo Clinic Minnesota, Rochester, Minnesota., Iyer PG; Division of Gastroenterology and Hepatology, Mayo Clinic Minnesota, Rochester, Minnesota. Electronic address: iyer.prasad@mayo.edu., Vela MF; Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Scottsdale, Arizona., Katzka DA; Division of Gastroenterology and Hepatology, Mayo Clinic Minnesota, Rochester, Minnesota.
Jazyk:	angličtina
Zdroj:	Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2018 May; Vol. 16 (5), pp. 608-617. Date of Electronic Publication: 2017 Jun 23.
DOI:	10.1016/j.cgh.2017.06.035
Abstrakt:	Dysfunction in the esophageal epithelial barrier function is a major source for morbidity. To better understand the pathophysiologic pathways of the diseases associated with barrier dysfunction, including gastroesophageal reflux disease, eosinophilic esophagitis, Barrett's esophagus, and obesity, it is important to understand the esophageal epithelial embryologic development, microscopic anatomy with a special focus on the barrier structure and function, extraepithelial defense mechanisms, and how these change in the diseased state. In recent years, significant progress has been made in elucidating the esophageal barrier structure and function both in vitro and in vivo. This has enhanced the understanding of mechanisms of disease, and may also allow identification of therapeutic targets that can help in the management of these diseases. This review provides a detailed discussion regarding the esophageal epithelial barrier structure and function, the current and historical techniques used to study the barrier, and how it is affected by common esophageal diseases. (Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu