Bioprinted three dimensional human tissues for toxicology and disease modeling.

Autor: Nguyen DG; Organovo Inc., 6275 Nancy Ridge Dr., San Diego, CA 92121, United States. Electronic address: dnguyen@organovo.com., Pentoney SL Jr; Organovo Inc., 6275 Nancy Ridge Dr., San Diego, CA 92121, United States.
Jazyk: angličtina
Zdroj: Drug discovery today. Technologies [Drug Discov Today Technol] 2017 Mar; Vol. 23, pp. 37-44. Date of Electronic Publication: 2017 Mar 28.
DOI: 10.1016/j.ddtec.2017.03.001
Abstrakt: The high rate of attrition among clinical-stage therapies, due largely to an inability to predict human toxicity and/or efficacy, underscores the need for in vitro models that better recapitulate in vivo human biology. In much the same way that additive manufacturing has revolutionized the production of solid objects, three-dimensional (3D) bioprinting is enabling the automated production of more architecturally and functionally accurate in vitro tissue culture models. Here, we provide an overview of the most commonly used bioprinting approaches and how they are being used to generate complex in vitro tissues for use in toxicology and disease modeling research.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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