Increased food intake after starvation enhances sleep in Drosophila melanogaster.

Autor: Regalado JM; Department of Biology, University of Nevada-Reno, Reno, NV 89557, USA., Cortez MB; Department of Biology, University of Nevada-Reno, Reno, NV 89557, USA., Grubbs J; Department of Biology, University of Nevada-Reno, Reno, NV 89557, USA., Link JA; Department of Biology, University of Nevada-Reno, Reno, NV 89557, USA., van der Linden A; Department of Biology, University of Nevada-Reno, Reno, NV 89557, USA., Zhang Y; Department of Biology, University of Nevada-Reno, Reno, NV 89557, USA. Electronic address: yongzhang@unr.edu.
Jazyk: angličtina
Zdroj: Journal of genetics and genomics = Yi chuan xue bao [J Genet Genomics] 2017 Jun 20; Vol. 44 (6), pp. 319-326. Date of Electronic Publication: 2017 Jun 13.
DOI: 10.1016/j.jgg.2017.05.006
Abstrakt: Feeding and sleep are highly conserved, interconnected behaviors essential for survival. Starvation has been shown to potently suppress sleep across species; however, whether satiety promotes sleep is still unclear. Here we use the fruit fly, Drosophila melanogaster, as a model organism to address the interaction between feeding and sleep. We first monitored the sleep of flies that had been starved for 24 h and found that sleep amount increased in the first 4 h after flies were given food. Increased sleep after starvation was due to an increase in sleep bout number and average sleep bout length. Mutants of translin or adipokinetic hormone, which fail to suppress sleep during starvation, still exhibited a sleep increase after starvation, suggesting that sleep increase after starvation is not a consequence of sleep loss during starvation. We also found that feeding activity and food consumption were higher in the first 10-30 min after starvation. Restricting food consumption in starved flies to 30 min was sufficient to increase sleep for 1 h. Although flies ingested a comparable amount of food at differing sucrose concentrations, sleep increase after starvation on a lower sucrose concentration was undetectable. Taken together, our results suggest that increased food intake after starvation enhances sleep and reveals a novel relationship between feeding and sleep.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
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