Metabolic control and periodontal treatment decreases elevated oxidative stress in the early phases of type 1 diabetes onset.

Autor: Aral CA; Division of Periodontology, Malatya Oral and Dental Health Hospital, The Turkish Ministry of Health, Malatya, Turkey. Electronic address: cuneytasimaral@gmail.com., Nalbantoğlu Ö; Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Hospital, İzmir, Turkey., Nur BG; Division of Pediatric Dentistry, Private Practice, İzmir, Turkey., Altunsoy M; Division of Pediatric Dentistry, Private Practice, İzmir, Turkey., Aral K; Division of Periodontology, Malatya Oral and Dental Health Hospital, The Turkish Ministry of Health, Malatya, Turkey.
Jazyk: angličtina
Zdroj: Archives of oral biology [Arch Oral Biol] 2017 Oct; Vol. 82, pp. 115-120. Date of Electronic Publication: 2017 Jun 12.
DOI: 10.1016/j.archoralbio.2017.06.009
Abstrakt: Objective: Recently, increasing concern has been focused on the contribution of oxidative stress in the pathology of periodontal disease and diabetes mellitus. Firstly, the present study aimed to analyze gingival crevicular fluid (GCF), salivary, and serum oxidative status in children with type 1 diabetes mellitus (T1DM) at diagnosis and systemically healthy children with and without gingivitis. Additionally, the diabetic patients were reevaluated after diabetes and periodontal treatment.
Design: The study groups were composed of 32 T1DM patients at diagnosis, and age- and gender-matched thirty-six systemically healthy children with (G) and without (H) gingivitis. The diabetic patients who took insulin therapy (1.5 units/kg/day totally) and periodontal treatment (oral hygiene education with professional scaling) were reevaluated after 3 months. The levels of total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were recorded.
Results: GCF, salivary, and serum OSI were elevated in group T1DM compared to the other groups at baseline (p<0.05), and decreased in group T1DM at reevaluation compared to baseline (p<0.05). GCF OSI was positively correlated with periodontal clinical parameters (p<0.05). Glycated hemoglobin was positively correlated with GCF TOS (r=0.302, p=0.007), GCF OSI (r=0.346, p=0.002), salivary TOS (r=0.326, p=0.046), and serum TOS (r=0.239, p=0.044).
Conclusion: The instability in the oxidative status that accompanies diabetes may be considered a significant pathogenic factor of diabetes-related periodontal inflammation.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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