A Simple Route to Strong Carbon-13 NMR Signals Detectable for Several Minutes.

Autor: Roy SS; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK., Norcott P; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK., Rayner PJ; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK., Green GGR; York Neuroimaging Centre, The Biocentre, York Science Park Innovation Way, Heslington, York, YO10 5NY, UK., Duckett SB; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2017 Aug 04; Vol. 23 (44), pp. 10496-10500. Date of Electronic Publication: 2017 Jul 19.
DOI: 10.1002/chem.201702767
Abstrakt: Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) suffer from low sensitivity and limited nuclear spin memory lifetimes. Although hyperpolarization techniques increase sensitivity, there is also a desire to increase relaxation times to expand the range of applications addressable by these methods. Here, we demonstrate a route to create hyperpolarized magnetization in 13 C nuclear spin pairs that last much longer than normal lifetimes by storage in a singlet state. By combining molecular design and low-field storage with para-hydrogen derived hyperpolarization, we achieve more than three orders of signal amplification relative to equilibrium Zeeman polarization and an order of magnitude extension in state lifetime. These studies use a range of specifically synthesized pyridazine derivatives and dimethyl p-tolyl phenyl pyridazine is the most successful, achieving a lifetime of about 190 s in low-field, which leads to a 13 C-signal that is visible for 10 minutes.
(© 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.)
Databáze: MEDLINE
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