| Autor: |
Akhrem AA, Kisel MA, Kozlov IA, Tsybovsky IS, Vulfson EN |
| Jazyk: |
angličtina |
| Zdroj: |
FEBS letters [FEBS Lett] 1985 Aug 05; Vol. 187 (2), pp. 249-52. |
| DOI: |
10.1016/0014-5793(85)81252-7 |
| Abstrakt: |
1,5-Difluoro-2,4-dinitrobenzene completely inhibits F1-ATPase when it is used at micromolar concentrations and the inhibitor/enzyme molar ratio is equal to 3. The inhibition can be reversed by dithiothreitol treatment. 7-Chloro-4-nitrobenzofurazan treatment of F1-ATPase does not prevent the reaction of the enzyme with 1,5-difluoro-2,4-dinitrobenzene. The 1,5-difluoro-2,4-dinitrobenzene-induced inhibition is thought to be a result of the modification of a tyrosine residue with pK 9.1. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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