Cytokine Signaling in the Development and Homeostasis of Regulatory T cells.
| Autor: | Toomer KH; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida 33136., Malek TR; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida 33136.; Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, Florida 33136. |
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| Jazyk: | angličtina |
| Zdroj: | Cold Spring Harbor perspectives in biology [Cold Spring Harb Perspect Biol] 2018 Mar 01; Vol. 10 (3). Date of Electronic Publication: 2018 Mar 01. |
| DOI: | 10.1101/cshperspect.a028597 |
| Abstrakt: | Cytokine signaling is indispensable for regulatory T-cell (Treg) development in the thymus, and also influences the homeostasis, phenotypic diversity, and function of Tregs in the periphery. Because Tregs are required for establishment and maintenance of immunological self-tolerance, investigating the role of cytokines in Treg biology carries therapeutic potential in the context of autoimmune disease. This review discusses the potent and diverse influences of interleukin (IL)-2 signaling on the Treg compartment, an area of knowledge that has led to the use of low-dose IL-2 as a therapy to reregulate autoaggressive immune responses. Evidence suggesting Treg-specific impacts of the cytokines transforming growth factor β (TGF-β), IL-7, thymic stromal lymphopoietin (TSLP), IL-15, and IL-33 is also presented. Finally, we consider the technical challenges and knowledge limitations that must be overcome to bring other cytokine-based, Treg-targeted therapies into clinical use. (Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved.) |
| Databáze: | MEDLINE |
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