Experience-dependent epigenomic reorganization in the hippocampus.
| Autor: | Duke CG; Department of Neurobiology, Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA., Kennedy AJ; Department of Chemistry, Bates College, Lewiston, Maine 04240, USA., Gavin CF; Department of Neurobiology, Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA., Day JJ; Department of Neurobiology, Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA., Sweatt JD; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37235, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Learning & memory (Cold Spring Harbor, N.Y.) [Learn Mem] 2017 Jun 15; Vol. 24 (7), pp. 278-288. Date of Electronic Publication: 2017 Jun 15 (Print Publication: 2017). |
| DOI: | 10.1101/lm.045112.117 |
| Abstrakt: | Using a hippocampus-dependent contextual threat learning and memory task, we report widespread, coordinated DNA methylation changes in CA1 hippocampus of Sprague-Dawley rats specific to threat learning at genes involved in synaptic transmission. Experience-dependent alternations in gene expression and DNA methylation were observed as early as 1 h following memory acquisition and became more pronounced after 24 h. Gene ontology analysis revealed significant enrichment of functional categories related to synaptic transmission in genes that were hypomethylated at 24 h following threat learning. Integration of these data sets with previously characterized epigenetic and transcriptional changes in brain disease states suggested significant overlap between genes regulated by memory formation and genes altered in memory-related neurological and neuropsychiatric diseases. These findings provide a comprehensive resource to aid in the identification of memory-relevant therapeutic targets. Our results shed new light on the gene expression and DNA methylation changes involved in memory formation, confirming that these processes are dynamic and experience-dependent. Finally, this work provides a roadmap for future studies to identify linkage of memory-associated genes to altered disease states. (© 2017 Duke et al.; Published by Cold Spring Harbor Laboratory Press.) |
| Databáze: | MEDLINE |
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