IGFBP7 Deletion Promotes Hepatocellular Carcinoma.

Autor:	Akiel M; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Guo C; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Li X; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Rajasekaran D; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Mendoza RG; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Robertson CL; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Jariwala N; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Yuan F; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Subler MA; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Windle J; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Garcia DK; Greehey Children's Cancer Research Institute, Virginia Commonwealth University, Richmond, Virginia., Lai Z; Greehey Children's Cancer Research Institute, Virginia Commonwealth University, Richmond, Virginia., Chen HH; Greehey Children's Cancer Research Institute, Virginia Commonwealth University, Richmond, Virginia., Chen Y; Greehey Children's Cancer Research Institute, Virginia Commonwealth University, Richmond, Virginia.; Department of Epidemiology and Biostatistics, University of Texas Health Science Center San Antonio, San Antonio, Texas., Giashuddin S; Department of Pathology, New York Presbyterian Health System at Weill Cornell Medical College, New York, New York., Fisher PB; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia.; VCUMassey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.; VCU Institute of Molecular Medicine (VIMM), Virginia Commonwealth University, Richmond, Virginia., Wang XY; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia.; VCUMassey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.; VCU Institute of Molecular Medicine (VIMM), Virginia Commonwealth University, Richmond, Virginia., Sarkar D; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia. devanand.sarkar@vcuhealth.org.; VCUMassey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.; VCU Institute of Molecular Medicine (VIMM), Virginia Commonwealth University, Richmond, Virginia.
Jazyk:	angličtina
Zdroj:	Cancer research [Cancer Res] 2017 Aug 01; Vol. 77 (15), pp. 4014-4025. Date of Electronic Publication: 2017 Jun 15.
DOI:	10.1158/0008-5472.CAN-16-2885
Abstrakt:	Activation of IGF signaling is a major oncogenic event in diverse cancers, including hepatocellular carcinoma (HCC). In this setting, the insulin-like growth factor binding protein IGFBP7 inhibits IGF signaling by binding the IGF1 receptor (IGF1R), functioning as a candidate tumor suppressor. IGFBP7 abrogates tumors by inhibiting angiogenesis and inducing cancer-specific senescence and apoptosis. Here, we report that Igfbp7-deficient mice exhibit constitutively active IGF signaling, presenting with proinflammatory and immunosuppressive microenvironments and spontaneous liver and lung tumors occurring with increased incidence in carcinogen-treated subjects. Igfbp7 deletion increased proliferation and decreased senescence of hepatocytes and mouse embryonic fibroblasts, effects that were blocked by treatment with IGF1 receptor inhibitor. Significant inhibition of genes regulating immune surveillance was observed in Igfbp7 -/- murine livers, which was associated with a marked inhibition in antigen cross-presentation by Igfbp7 -/- dendritic cells. Conversely, IGFBP7 overexpression inhibited growth of HCC cells in syngeneic immunocompetent mice. Depletion of CD4 + or CD8 + T lymphocytes abolished this growth inhibition, identifying it as an immune-mediated response. Our findings define an immune component of the pleiotropic mechanisms through which IGFBP7 suppresses HCC. Furthermore, they offer a genetically based preclinical proof of concept for IGFBP7 as a therapeutic target for immune management of HCC. Cancer Res; 77(15); 4014-25. ©2017 AACR . (©2017 American Association for Cancer Research.)
Databáze:	MEDLINE
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