Total Synthesis of the Cyclic Dodecapeptides Wewakazole and Wewakazole B.
| Autor: | Inman M; School of Chemistry, University of Nottingham , University Park, Nottingham NG2 7RD, U.K., Dexter HL; School of Chemistry, University of Nottingham , University Park, Nottingham NG2 7RD, U.K., Moody CJ; School of Chemistry, University of Nottingham , University Park, Nottingham NG2 7RD, U.K. |
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| Jazyk: | angličtina |
| Zdroj: | Organic letters [Org Lett] 2017 Jul 07; Vol. 19 (13), pp. 3454-3457. Date of Electronic Publication: 2017 Jun 15. |
| DOI: | 10.1021/acs.orglett.7b01393 |
| Abstrakt: | The cyclic dodecapeptides wewakazole and wewakazole B have been synthesized by a divergent strategy via a common tris-proline containing oxazole octapeptide and two separate bis-oxazole containing tetrapeptide units, followed by peptide coupling and macrocyclization. The three oxazole amino acid fragments are readily accessible by rhodium(II)-catalyzed amide N-H insertion of diazocarbonyl compounds, or by the cycloaddition of rhodium carbenoids with nitriles. |
| Databáze: | MEDLINE |
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