Prevalence of group A genotype human rotavirus among children with diarrhoea in Nepal, 2009-2011.
| Autor: | Sherchand JB; Tribhuvan University Institute of Medicine, Public Health Research Laboratory and Microbiology., Schluter WW; Program for Immunization Preventable Diseases (IPD), Kathmandu, Nepal., Sherchan JBSB; Department of Microbiology, Kathmandu University School of Medical Sciences, Dhulikhel, Nepal., Tandukar S; Tribhuvan University Institute of Medicine, Public Health Research Laboratory and Microbiology., Dhakwa JR; Kanti Children's Hospital, Maharajgunj, Kathmandu, Nepal., Choudhary GR; Program for Immunization Preventable Diseases (IPD), Kathmandu, Nepal., Mahasethd C; Kanti Children's Hospital, Maharajgunj, Kathmandu, Nepal. |
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| Jazyk: | angličtina |
| Zdroj: | WHO South-East Asia journal of public health [WHO South East Asia J Public Health] 2012 Oct-Dec; Vol. 1 (4), pp. 432-440. |
| DOI: | 10.4103/2224-3151.207045 |
| Abstrakt: | Background: Rotavirus as a causative agent of childhood diarrhea is known to cause serious illness among children less than 5 years of age. This study examined the epidemiology of rotavirus disease burden and diversity of G and P genotypes of rotavirus in Nepal. Methods: Stool samples were tested for rotavirus by Enzyme Immuno Assay and Group A rotaviruses were detected by using both ELISA and RT-PCR in 2718 samples between 2009 and 2011. Results: Rotavirus was more frequently detected among inpatients (28.5%) than outpatients (15.2%). Over the three-year study period, 653 (24.4%) cases were positive for rotavirus by ELISA. Genotyping by RT-PCR was done on 638 samples. The most prevalent genotype was G12P [6] (60.4%). Mixed infections were not uncommon (14% in 2009, 29% in 2010 an 7% in 2011). However, 41 were partially typed and 23 were completely untyped over the study period. Conclusions: This study highlights the rotavirus disease burden and diversity of rotavirus strains circulating in Nepal. Continued sentinel surveillance will provide useful information to policy makers with regard to rotavirus vaccine introduction. |
| Databáze: | MEDLINE |
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