Short-term air pollution exposure decreases lung function: a repeated measures study in healthy adults.

Autor: Int Panis L; Flemish Institute for Technological Research (VITO), Boeretang 200, 2400, Mol, Belgium. luc.intpanis@vito.be.; Transportation Research Institute, Hasselt University, Diepenbeek, Belgium. luc.intpanis@vito.be., Provost EB; Flemish Institute for Technological Research (VITO), Boeretang 200, 2400, Mol, Belgium.; Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium., Cox B; Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium., Louwies T; Flemish Institute for Technological Research (VITO), Boeretang 200, 2400, Mol, Belgium.; Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium., Laeremans M; Flemish Institute for Technological Research (VITO), Boeretang 200, 2400, Mol, Belgium.; Transportation Research Institute, Hasselt University, Diepenbeek, Belgium., Standaert A; Flemish Institute for Technological Research (VITO), Boeretang 200, 2400, Mol, Belgium., Dons E; Flemish Institute for Technological Research (VITO), Boeretang 200, 2400, Mol, Belgium.; Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium., Holmstock L; The Belgian Nuclear Research Centre (SCK●CEN), Mol, Belgium., Nawrot T; Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.; Department of Public Health, Leuven University (KU Leuven), Leuven, Belgium., De Boever P; Flemish Institute for Technological Research (VITO), Boeretang 200, 2400, Mol, Belgium.; Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
Jazyk: angličtina
Zdroj: Environmental health : a global access science source [Environ Health] 2017 Jun 14; Vol. 16 (1), pp. 60. Date of Electronic Publication: 2017 Jun 14.
DOI: 10.1186/s12940-017-0271-z
Abstrakt: Background: Daily changes in ambient concentrations of particulate matter, nitrogen oxides and ozone are associated with increased cardiopulmonary morbidity and mortality, with the lungs and their function being a vulnerable target.
Methods: To evaluate the association between daily changes in air pollution and lung function in healthy adults we obtained annual lung function measurements from a routine worker health surveillance program not designed for research purposes. Forced Vital Capacity (FVC), Forced Expiratory Volume in the first second (FEV1), FEV1/FVC and Peak Expiratory flow (PEF) from a cohort of 2449 employees were associated with daily measurements of PM 10 , NO 2 and ozone at a nearby monitoring station in the North of Belgium. Repeated measures were available for the period 2011-2015.
Results: The mean (SD) PM 10 concentration on the day of the lung function test was 24.9 (15.5) μg/m 3 . A 10 μg PM 10 /m 3 increase on the day of the clinical examination was associated with a 18.9 ml lower FVC (95% CI: -27.5 to -10.3, p < 0.0001), 12.8 ml lower FEV1 (-19.1 to -6.5; p < 0.0001), and a 51.4 ml/s lower PEF (-75.0 to -27.0; p < 0.0001). The FEV1/FVC-ratio showed no associations. An increase of 10 μgNO 2 /m 3 was associated with a reduction in PEF (-66.1 ml/s (-106.6 to -25.6; p < 0.001)) on the day of the examination.
Conclusions: We found negative associations between daily variations in ambient air pollution and FVC, FEV1 and PEF in healthy adults.
Databáze: MEDLINE
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