Hepatitis B testing and treatment in HIV patients in The Gambia-Compliance with international guidelines and clinical outcomes.

Autor: Ndow G; Division of Digestive Diseases, Department of Surgery & Cancer, St. Mary's Hospital Campus, Imperial College London, United Kingdom.; Hepatitis Unit, Disease Control & Elimination, MRC Unit The Gambia, Fajara, The Gambia., Gore ML; Section of Virology, Department of Medicine, Imperial College London, London, United Kingdom., Shimakawa Y; Unité d'Épidémiologie des Maladies Émergentes, Institut Pasteur, Paris, France., Suso P; Hepatitis Unit, Disease Control & Elimination, MRC Unit The Gambia, Fajara, The Gambia., Jatta A; Hepatitis Unit, Disease Control & Elimination, MRC Unit The Gambia, Fajara, The Gambia., Tamba S; Hepatitis Unit, Disease Control & Elimination, MRC Unit The Gambia, Fajara, The Gambia., Sow A; Laboratoire Bactériologie-Virologie, CHU Aristide Le Dantec, Université Cheikh Anta DIOP, Dakar, Senegal., Touré-Kane C; Laboratoire Bactériologie-Virologie, CHU Aristide Le Dantec, Université Cheikh Anta DIOP, Dakar, Senegal., Sadiq F; Division of Digestive Diseases, Department of Surgery & Cancer, St. Mary's Hospital Campus, Imperial College London, United Kingdom., Sabally S; Hands on Care HIV Clinic, Brikama Health Centre, Brikama, The Gambia., Njie R; Hepatitis Unit, Disease Control & Elimination, MRC Unit The Gambia, Fajara, The Gambia.; International Agency for Research on Cancer (IARC), WHO, Lyon, France., Thursz MR; Division of Digestive Diseases, Department of Surgery & Cancer, St. Mary's Hospital Campus, Imperial College London, United Kingdom., Lemoine M; Division of Digestive Diseases, Department of Surgery & Cancer, St. Mary's Hospital Campus, Imperial College London, United Kingdom.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2017 Jun 14; Vol. 12 (6), pp. e0179025. Date of Electronic Publication: 2017 Jun 14 (Print Publication: 2017).
DOI: 10.1371/journal.pone.0179025
Abstrakt: Background: Compliance with WHO guidelines on HBV screening and treatment in HIV-coinfected patients is often challenging in resource limited countries and has been poorly assessed in sub-Saharan Africa.
Methods: Between 2015 and 2016, we assessed physician's compliance with WHO guidelines on HIV-HBV coinfection in the largest HIV clinic in The Gambia, and the hepatic outcomes in HIV-HBV coinfected patients as compared to randomly selected HIV-monoinfected controls.
Results: 870 HIV-infected patients regularly seen in this clinic agreed to participate in our study. Only 187 (21.5%, 95% CI 18.8-24.3) had previously been screened for HBsAg, 23 (12.3%, 95% CI 8.0-17.9) were positive of whom none had liver assessment and only 6 (26.1%) had received Tenofovir. Our HBV testing intervention was accepted by all participants and found 94/870 (10.8%, 95% CI 8.8-13.1) positive, 78 of whom underwent full liver assessment along with 40 HBsAg-negative controls. At the time of liver assessment, 61/78 (78.2%) HIV-HBV coinfected patients received ART with 7 (11.5%) on Tenofovir and 54 (88.5%) on Lamivudine alone. HIV-HBV coinfected patients had higher APRI score compared to controls (0.58 vs 0.42, p = 0.002). HBV DNA was detectable in 52/53 (98.1%) coinfected patients with 14/53 (26.4%) having HBV DNA >20,000 IU/L. 10/12 (83.3%) had at least one detectable 3TC-associated HBV resistance, which tended to be associated with increase in liver fibrosis after adjusting for age and sex (p = 0.05).
Conclusions: Compliance with HBV testing and treatment guidelines is poor in this Gambian HIV programme putting coinfected patients at risk of liver complications. However, the excellent uptake of HBV screening and linkage to care in our study suggests feasible improvements.
Databáze: MEDLINE
Externí odkaz: