Elucidation of the elusive structure and formula of the active pharmaceutical ingredient bismuth subgallate by continuous rotation electron diffraction.

Autor: Wang Y; Department of Material and Environmental Chemistry, Stockholm University, 106 91 Stockholm, Sweden. andrew.inge@mmk.su.se., Takki S; Department of Material and Environmental Chemistry, Stockholm University, 106 91 Stockholm, Sweden. andrew.inge@mmk.su.se., Cheung O; School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK., Xu H; Department of Material and Environmental Chemistry, Stockholm University, 106 91 Stockholm, Sweden. andrew.inge@mmk.su.se., Wan W; Department of Material and Environmental Chemistry, Stockholm University, 106 91 Stockholm, Sweden. andrew.inge@mmk.su.se., Öhrström L; Department of Chemistry and Chemical Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden., Inge AK; Department of Material and Environmental Chemistry, Stockholm University, 106 91 Stockholm, Sweden. andrew.inge@mmk.su.se.
Jazyk: angličtina
Zdroj: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2017 Jul 04; Vol. 53 (52), pp. 7018-7021. Date of Electronic Publication: 2017 Jun 14.
DOI: 10.1039/c7cc03180g
Abstrakt: Bismuth subgallate has been used in wound and gastrointestinal therapy for over a century. The combination of continuous rotation electron diffraction and sample cooling finally revealed its structure as a coordination polymer. The structure provides insight regarding its formula, poor solubility, acid resistance and previously unreported gas sorption properties.
Databáze: MEDLINE