Exploiting natural killer group 2D receptors for CAR T-cell therapy.

Autor: Demoulin B; Research & Development Department, Celyad SA, Mont-Saint-Guibert, Belgium., Cook WJ; Center for Sy+nthetic Immunity, Department of Microbiology & Immunology, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA., Murad J; Celdara Medical, LLC, Lebanon, NH, USA., Graber DJ; Center for Sy+nthetic Immunity, Department of Microbiology & Immunology, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA., Sentman ML; Center for Sy+nthetic Immunity, Department of Microbiology & Immunology, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA., Lonez C; Research & Development Department, Celyad SA, Mont-Saint-Guibert, Belgium., Gilham DE; Research & Development Department, Celyad SA, Mont-Saint-Guibert, Belgium., Sentman CL; Center for Sy+nthetic Immunity, Department of Microbiology & Immunology, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA., Agaugue S; Research & Development Department, Celyad SA, Mont-Saint-Guibert, Belgium.
Jazyk: angličtina
Zdroj: Future oncology (London, England) [Future Oncol] 2017 Aug; Vol. 13 (18), pp. 1593-1605. Date of Electronic Publication: 2017 Jun 14.
DOI: 10.2217/fon-2017-0102
Abstrakt: Chimeric antigen receptors (CARs) are genetically engineered proteins that combine an extracellular antigen-specific recognition domain with one or several intracellular T-cell signaling domains. When expressed in T cells, these CARs specifically trigger T-cell activation upon antigen recognition. While the clinical proof of principle of CAR T-cell therapy has been established in hematological cancers, CAR T cells are only at the early stages of being explored to tackle solid cancers. This special report discusses the concept of exploiting natural killer cell receptors as an approach that could broaden the specificity of CAR T cells and potentially enhance the efficacy of this therapy against solid tumors. New data demonstrating feasibility of this approach in humans and supporting the ongoing clinical trial are also presented.
Databáze: MEDLINE
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