Should isolated fetal ventriculomegaly measured below 12 mm be viewed as a variant of the norm? Results of a 5-year experience in a prenatal referral center.

Autor:	Lavongtheung A; a Department of Obstetrics and Gynecology , University Hospital of Amiens , CHU Amiens Sud , Amiens CEDEX 1 , France., Jedraszak G; b Department of Genetics , University Hospital of Amiens , CHU Amiens Sud , Amiens CEDEX 1 , France., Naepels P; a Department of Obstetrics and Gynecology , University Hospital of Amiens , CHU Amiens Sud , Amiens CEDEX 1 , France., Tourneux P; c Department of Neonatology , University Hospital of Amiens , CHU Amiens Sud , Amiens CEDEX 1 , France., Gondry-Jouet C; d Department of Radiology , University Hospital of Amiens , CHU Amiens Sud , Amiens CEDEX 1 , France., Le Moing AG; e Department of Pediatric Neurology , University Hospital of Amiens , CHU Amiens Sud , Amiens CEDEX 1 , France., Gondry J; a Department of Obstetrics and Gynecology , University Hospital of Amiens , CHU Amiens Sud , Amiens CEDEX 1 , France., Chevreau J; a Department of Obstetrics and Gynecology , University Hospital of Amiens , CHU Amiens Sud , Amiens CEDEX 1 , France.
Jazyk:	angličtina
Zdroj:	The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2018 Sep; Vol. 31 (17), pp. 2325-2331. Date of Electronic Publication: 2017 Jul 11.
DOI:	10.1080/14767058.2017.1342801
Abstrakt:	Background: Fetal ventriculomegaly (VM) is defined as lateral ventricles measured above 10 mm. Some authors believe VM <12 mm are variants of the norm and need not be addressed for referral ultrasound. Methods: A retrospective continuous cohort study of 127 confirmed fetal VM was divided into three groups after initial referral sonographic assessment: isolated VM <12 mm (group A), isolated VM ≥12 mm (group B), and VM associated with other malformations (group C). We reviewed obstetric outcome and neonate evolution after 1 month with the aim of defining a pertinent prenatal workup. Results: We reported fetal infections in all groups (p = .24) and chromosomal abnormalities only in group C (p = .41). Fetal magnetic resonance imaging (MRI) found initially undiagnosed brain abnormalities in groups B and C (12.5 and 14.1%, p < .05). Ratios of healthy children after 1 month stemming, respectively, from groups A, B, and C were 66.7, 62.5, and 20.2% (p < .05). Conclusions: Our results are in favor of a systematic referral ultrasound for every fetal VM, regardless of size, as soon as definition criterion is met. Additional paraclinical assessment (maternal serologic status for toxoplasmosis and cytomegalovirus, amniocentesis, fetal cerebral MRI) should be discussed depending on the situation.
Databáze:	MEDLINE
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