HPLC analysis of furazolidone in goats given the therapeutic dose.

Autor: Mustafa AI, Ali BH, Satti AM
Jazyk: angličtina
Zdroj: Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology [Comp Biochem Physiol C Comp Pharmacol Toxicol] 1985; Vol. 81 (1), pp. 167-9.
DOI: 10.1016/0742-8413(85)90109-4
Abstrakt: Furazolidone (FZ) was given to Nubian goats at the recommended therapeutic dose of 10 mg/kg body wt, for 5 days. The animals were slaughtered 24 hr after the last dose, and their livers, gluteal muscles, kidneys and hearts analysed for FZ residues by an HPLC method with a detection limit of 0.05 micrograms g-1. The drug was detected in the muscle and liver at concentrations of 0.256 +/- 0.009, 0.101 +/- 0.016 micrograms g-1 tissue, respectively. No detectable concentrations of the drug were found in the kidney and heart.
Databáze: MEDLINE