Graft predominance after double umbilical cord blood transplantation: a review.

Autor:	Cornelissen JJ; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Kalin B; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Lamers CHJ; Laboratory of Tumor Immunology, Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	Stem cell investigation [Stem Cell Investig] 2017 May 26; Vol. 4, pp. 47. Date of Electronic Publication: 2017 May 26 (Print Publication: 2017).
DOI:	10.21037/sci.2017.05.09
Abstrakt:	Several parameters are involved in graft predominance after double umbilical cord blood transplantation (dUCBT), of which T-cell alloreactivity between the grafts is now considered to be the major denominator. We recently showed that alloreactive CD4+ T-cells originating from the predominant CBU recognize HLA-class II allele mismatches and can readily be detected in the majority of patients. In addition, it was shown that HLA-class II allele-specific CD4+ T-cells were able to recognize primary leukemic cells when the mismatched HLA-class II allele was shared between the rejected CBU and the patient. These results further underscored the role of alloreactive T-cells, notably class II specific CD4+ T-cells, in graft-versus-graft reactions and in graft-versus-leukemia after dUCBT. Competing Interests: Conflicts of Interest: The authors have no conflicts of interest to declare.
Databáze:	MEDLINE
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