A translational approach to capture gait signatures of neurological disorders in mice and humans.

Autor:	Broom L; Department of Neurology, Division of Movement Disorders, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Ellison BA; Department of Neurology, Division of Movement Disorders, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Worley A; Department of Neurology, Division of Movement Disorders, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Wagenaar L; Department of Neurology, Division of Movement Disorders, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Sörberg E; Department of Neurology, Division of Movement Disorders, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Ashton C; Department of Neurology, Division of Movement Disorders, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Il 60612, USA., Buchman AS; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Il 60612, USA., Saper CB; Department of Neurology, Division of Movement Disorders, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Shih LC; Department of Neurology, Division of Movement Disorders, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Hausdorff JM; Center for the Study of Movement Cognition and Mobility, Tel-Aviv Sourasky Medical Center, Tel Aviv, 64239, Israel.; Sagol School of Neuroscience and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel., VanderHorst VG; Department of Neurology, Division of Movement Disorders, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA. vvanderh@bidmc.harvard.edu.
Jazyk:	angličtina
Zdroj:	Scientific reports [Sci Rep] 2017 Jun 12; Vol. 7 (1), pp. 3225. Date of Electronic Publication: 2017 Jun 12.
DOI:	10.1038/s41598-017-03336-1
Abstrakt:	A method for capturing gait signatures in neurological conditions that allows comparison of human gait with animal models would be of great value in translational research. However, the velocity dependence of gait parameters and differences between quadruped and biped gait have made this comparison challenging. Here we present an approach that accounts for changes in velocity during walking and allows for translation across species. In mice, we represented spatial and temporal gait parameters as a function of velocity and established regression models that reproducibly capture the signatures of these relationships during walking. In experimental parkinsonism models, regression curves representing these relationships shifted from baseline, implicating changes in gait signatures, but with marked differences between models. Gait parameters in healthy human subjects followed similar strict velocity dependent relationships which were altered in Parkinson's patients in ways that resemble some but not all mouse models. This novel approach is suitable to quantify qualitative walking abnormalities related to CNS circuit dysfunction across species, identify appropriate animal models, and it provides important translational opportunities.
Databáze:	MEDLINE
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