Subclinical myocardial disease by cardiac magnetic resonance imaging and spectroscopy in healthy HIV/Hepatitis C virus-coinfected persons.

Autor:	Chew KW; 1 Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Liu CY; 2 National Institutes of Health, Bethesda, MD, USA.; 3 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ambale-Venkatesh B; 3 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Liao D; 1 Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Horwich TB; 1 Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Lima JAC; 3 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Bluemke DA; 2 National Institutes of Health, Bethesda, MD, USA.; 3 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Paul Finn J; 4 Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Butt AA; 5 VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.; 6 Weill Cornell Medical College, Doha, Qatar and New York, NY, USA.; 7 Hamad Healthcare Quality Institute and Hamad Medical Corporation, Doha, Qatar., Currier JS; 1 Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Jazyk:	angličtina
Zdroj:	The Journal of international medical research [J Int Med Res] 2017 Dec; Vol. 45 (6), pp. 1693-1707. Date of Electronic Publication: 2017 Jun 12.
DOI:	10.1177/0300060517708919
Abstrakt:	Objective The contribution of hepatitis C virus (HCV) infection to the risk of heart failure in human immunodeficiency virus (HIV)-coinfected persons is unknown. The objective was to characterize cardiac function and morphology in HIV-treated coinfected persons. Methods In a cross-sectional study, HIV-infected patients virologically suppressed on antiretroviral therapy without known cardiovascular disease or diabetes mellitus underwent cardiac magnetic resonance imaging and spectroscopy for measures of cardiac function, myocardial fibrosis, and steatosis. Results The study included 18 male patients with a median age of 44 years. Of these, 10 had untreated HCV coinfection and eight had HIV monoinfection. Global systolic and diastolic function in the cohort were normal, and median myocardial fat content was 0.48% (interquartile range 0.35-1.54). Left ventricular (LV) mass index and LV mass/volume ratio were significantly greater in the HIV/HCV-coinfected group compared with the HIV-monoinfected group. In the HIV-monoinfected group, there was more myocardial fibrosis as measured by extracellular volume fraction. Conclusions There were differences between HIV/HCV-coinfected and HIV-monoinfected patients in cardiac structure and morphology. Larger studies are needed to examine whether HIV and HCV independently contribute to mechanisms of heart failure.
Databáze:	MEDLINE
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