Useful Effects of Melatonin in Peripheral Nerve Injury and Development of the Nervous System.

Autor:	Uyanikgil Y; Department of Histology and Embryology, Faculty of Medicine, Ege University, İzmir, Turkey.; Cord Blood, Cell-Tissue Research and Application Center, Ege University, İzmir, Turkey., Cavusoglu T; Department of Histology and Embryology, Faculty of Medicine, Ege University, İzmir, Turkey.; Cord Blood, Cell-Tissue Research and Application Center, Ege University, İzmir, Turkey., Kılıc KD; Department of Histology and Embryology, Faculty of Medicine, Ege University, İzmir, Turkey., Yigitturk G; Department of Histology and Embryology, Faculty of Medicine, Ege University, İzmir, Turkey., Celik S; Department of Anatomy, Faculty of Medicine, Ege University, İzmir, Turkey., Tubbs RS; Seattle Science Foundation, Seattle, Washington, United States., Turgut M; Department of Neurosurgery, Adnan Menderes University School of Medicine, Aydın, Turkey.
Jazyk:	angličtina
Zdroj:	Journal of brachial plexus and peripheral nerve injury [J Brachial Plex Peripher Nerve Inj] 2017 Feb 16; Vol. 12 (1), pp. e1-e6. Date of Electronic Publication: 2017 Feb 16 (Print Publication: 2017).
DOI:	10.1055/s-0036-1597838
Abstrakt:	This review summarizes the role of melatonin (MLT) in defense against toxic-free radicals and its novel effects in the development of the nervous system, and the effect of endogenously produced and exogenously administered MLT in reducing the degree of tissue and nerve injuries. MLT was recently reported to be an effective free radical scavenger and antioxidant. Since endogenous MLT levels fall significantly in senility, these findings imply that the loss of this antioxidant could contribute to the incidence or severity of some age-related neurodegenerative diseases. Considering the high efficacy of MLT in overcoming much of the injury not only to the peripheral nerve but also to other organs, clinical trials for this purpose should be seriously considered.
Databáze:	MEDLINE
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