Electrochemical oxidation mechanism of eugenol on graphene modified carbon paste electrode and its analytical application to pharmaceutical analysis.

Autor: Yildiz G; Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Maslak, Istanbul 34469, Turkey. Electronic address: gyildiz@itu.edu.tr., Aydogmus Z; Department of Analytical Chemistry, Faculty of Pharmacy, Istanbul University, Beyazıt, 34116 Istanbul, Turkey., Cinar ME; Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Maslak, Istanbul 34469, Turkey; Department Chemie-Biologie, OC1, Universität Siegen, Adolf-Reichwein-Str., 57068 Siegen, Germany., Senkal F; Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Maslak, Istanbul 34469, Turkey., Ozturk T; Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Maslak, Istanbul 34469, Turkey; Chemistry Group Laboratories, TUBITAK UME, PO Box 54, 41470 Gebze, Kocaeli, Turkey. Electronic address: ozturktur@itu.edu.tr.
Jazyk: angličtina
Zdroj: Talanta [Talanta] 2017 Oct 01; Vol. 173, pp. 1-8. Date of Electronic Publication: 2017 May 22.
DOI: 10.1016/j.talanta.2017.05.056
Abstrakt: Electrochemical properties of eugenol were investigated on a graphene modified carbon paste electrode (CPE) by using voltammetric methods, which exhibited a well-defined irreversible peak at about 0.7V vs Ag/AgCl, NaCl (3M) in Britton-Robinson buffer at pH 2.0. Mechanism of the electrochemical reaction of eugenol was studied by performing density functional theory (DFT) computations and mass spectroscopic analysis. (CPCM:water)-wB97XD/aug-cc-PVTZ//(CPCM:water)-wB97XD/6-31G(d) level calculations predicted that the formation of product P2, possessing a para-quinoid structure, is preferred rather than the product P1, suggested in the literature, having an ortho-quinoid system. Determination of eugenol in a pharmaceutical sample was realized in the light of the electrochemical findings, and a validated voltammetric method for quantitative analysis of eugenol in a pharmaceutical formulation was proposed. The differential pulse voltammogram (DPV) peak currents were found to be linear in the concentration range of 1.0 × 10 -7 to 1.7 × 10 -5 M. The limit of detection (LOD) and the limit of quantification (LOQ) were obtained to be 7.0 × 10 -9 and 2.3 × 10 -8 , respectively.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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