A Diagnostic Approach to Recurrent Orofacial Swelling: A Retrospective Study of 104 Patients.

Autor:	Miest RY; Department of Dermatology, Mayo Clinic, Rochester, MN., Bruce AJ; Department of Dermatology, Mayo Clinic, Jacksonville, FL. Electronic address: bruce.alison@mayo.edu., Comfere NI; Department of Dermatology, Mayo Clinic, Rochester, MN; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Hadjicharalambous E; Wayne State University School of Medicine, Detroit, MI., Endly D; Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ., Lohse CM; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN., Rogers RS 3rd; Department of Dermatology, Mayo Clinic, Scottsdale, AZ.
Jazyk:	angličtina
Zdroj:	Mayo Clinic proceedings [Mayo Clin Proc] 2017 Jul; Vol. 92 (7), pp. 1053-1060. Date of Electronic Publication: 2017 Jun 07.
DOI:	10.1016/j.mayocp.2017.03.015
Abstrakt:	Objective: To identify patients evaluated in an outpatient setting at our institution with a presentation of recurrent orofacial swelling and to review the spectrum of causes to outline a diagnostic approach. Patients and Methods: A retrospective study of 104 patients with more than 1 episode of orofacial swelling lasting for more than 5 days identified through a keyword search of the electronic health record from January 2, 2000, through July 5, 2011. Results: Patients were categorized according to final cause of orofacial swelling: idiopathic orofacial granulomatosis, solid facial edema due to rosacea and acne vulgaris, Crohn disease, contact dermatitis, sarcoidosis, exfoliative cheilitis, lichen planus, actinic cheilitis, cheilitis glandularis, lymphedema, miscellaneous, and multifactorial. Granulomatous inflammation was noted on biopsy in 40 of 85 patients (47%). Oral involvement was associated with Crohn disease (P<.001), and facial and periorbital swelling was associated with solid facial edema in the setting of rosacea and acne vulgaris (P<.001). Conclusion: The broad range of diagnoses responsible for recurrent orofacial swelling underscores the diagnostic challenge and importance of a thorough multidisciplinary evaluation to identify underlying causes. (Copyright © 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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