Tomato (Lycopersicon esculentum) or lycopene supplementation attenuates ventricular remodeling after myocardial infarction through different mechanistic pathways.

Autor: Pereira BLB; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu, Brazil. Electronic address: bruh_leticia@hotmail.com., Reis PP; Department of Surgery and Orthopedics, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu, Brazil. Electronic address: preis@fmb.unesp.br., Severino FE; Department of Surgery and Orthopedics, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu, Brazil. Electronic address: fabio.bjj@gmail.com., Felix TF; Department of Surgery and Orthopedics, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu, Brazil. Electronic address: felix.tainara@gmail.com., Braz MG; Department of Anesthesiology, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu, Brazil. Electronic address: mgbraz@hotmail.com., Nogueira FR; Department of Anesthesiology, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu, Brazil. Electronic address: flaviarnogueira@hotmail.com., Silva RAC; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu, Brazil. Electronic address: renata_candido88@yahoo.com.br., Cardoso AC; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu, Brazil. Electronic address: acarolcardoso@yahoo.com.br., Lourenço MAM; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu, Brazil. Electronic address: angelyca.lourenco@gmail.com., Figueiredo AM; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu, Brazil. Electronic address: amanda.mfigueiredo@yahoo.com.br., Chiuso-Minicucci F; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu, Brazil. Electronic address: ferchiuso@gmail.com., Azevedo PS; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu, Brazil. Electronic address: paulasa@fmb.unesp.br., Polegato BF; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu, Brazil. Electronic address: berthafurlan@fmb.unesp.br., Okoshi K; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu, Brazil. Electronic address: katashi@fmb.unesp.br., Fernandes AAH; Chemistry and Biochemistry Department, Institute of Biosciences, Univ Estadual Paulista (UNESP), Botucatu, Brazil. Electronic address: angelica@ibb.unesp.br., Paiva SAR; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu, Brazil. Electronic address: paiva@fmb.unesp.br., Zornoff LAM; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu, Brazil. Electronic address: lzornoff@fmb.unesp.br., Minicucci MF; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu, Brazil. Electronic address: minicucci@fmb.unesp.br.
Jazyk: angličtina
Zdroj: The Journal of nutritional biochemistry [J Nutr Biochem] 2017 Aug; Vol. 46, pp. 117-124. Date of Electronic Publication: 2017 Jun 01.
DOI: 10.1016/j.jnutbio.2017.05.010
Abstrakt: The objective of this study was to evaluate the influence of tomato or lycopene supplementation on cardiac remodeling after myocardial infarction (MI). Male Wistar rats were assigned to four groups: the sham group (animals that underwent simulated surgery) that received a standard chow (S; n=18), the infarcted group that received a standard chow (MI; n=13), the infarcted group supplemented with lycopene (1 mg of lycopene/kg body weight/day) (MIL; n=16) and the infarcted group supplemented with tomato (MIT; n=16). After 3 months, morphological, functional and biochemical analyses were performed. The groups MIL and MIT showed decreased interstitial fibrosis induced by infarction. Tomato supplementation attenuated the hypertrophy induced by MI. In addition, tomato and lycopene improved diastolic dysfunction evaluated by echocardiographic and isolated heart studies, respectively. The MI group showed higher levels of cardiac TNF-α compared to the MIL and MIT groups. Decreased nuclear factor E2-related factor 2 was measured in the MIL group. Lipid hydroperoxide levels were higher in the infarcted groups; however, the MIT group had a lower concentration than did the MI group [S=223±20.8, MI=298±19.5, MIL=277±26.6, MIT=261±28.8 (nmol/g); n=8; P<.001]. We also examined left ventricle miRNA expression; when compared to the S group, the MIL group uniquely down-regulated the expression of eight miRNAs. No miRNA was found to be up-regulated uniquely in the MIT and MIL groups. In conclusion, tomato or lycopene supplementation attenuated the cardiac remodeling process and improved diastolic function after MI. However, the effect of lycopene and tomato supplementation occurred through different mechanistic pathways.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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