Energy conserving thermoregulatory patterns and lower disease severity in a bat resistant to the impacts of white-nose syndrome.

Autor: Moore MS; Department of Biology, Bucknell University, Lewisburg, PA, 17837, USA.; College of Integrative Sciences and Arts, Arizona State University at the Polytechnic Campus, Mesa, AZ, 85212, USA., Field KA; Department of Biology, Bucknell University, Lewisburg, PA, 17837, USA., Behr MJ; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI, 53706, USA., Turner GG; Pennsylvania Game Commission, Harrisburg, PA, 17110, USA., Furze ME; Department of Biology, Bucknell University, Lewisburg, PA, 17837, USA., Stern DWF; Department of Biology, Bucknell University, Lewisburg, PA, 17837, USA., Allegra PR; Department of Biology, Bucknell University, Lewisburg, PA, 17837, USA., Bouboulis SA; Department of Biology, Bucknell University, Lewisburg, PA, 17837, USA., Musante CD; Department of Biology, Bucknell University, Lewisburg, PA, 17837, USA., Vodzak ME; Department of Biology, Bucknell University, Lewisburg, PA, 17837, USA., Biron ME; Department of Biology, Bucknell University, Lewisburg, PA, 17837, USA., Meierhofer MB; Department of Biology, Bucknell University, Lewisburg, PA, 17837, USA., Frick WF; Department of Ecology and Evolutionary Biology, University of California Santa Cruz, Santa Cruz, CA, 95064, USA., Foster JT; Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ, 86011, USA.; Department of Molecular, Cellular and Biomedical Science, University of New Hampshire, Durham, NH, 03824, USA., Howell D; Iowa Department of Natural Resources, Des Moines, IA, 50319-0034, USA., Kath JA; Illinois Department of Natural Resources, Springfield, IL, 62702, USA., Kurta A; Department of Biology, Eastern Michigan University, Ypsilanti, MI, 48197, USA., Nordquist G; Minnesota Department of Natural Resources, St. Paul, MN, 55155-4015, USA., Johnson JS; Department of Biology, Bucknell University, Lewisburg, PA, 17837, USA.; Department of Biological Sciences, Ohio University, Athens, USA., Lilley TM; Department of Biology, Bucknell University, Lewisburg, PA, 17837, USA., Barrett BW; Department of Biology, Bucknell University, Lewisburg, PA, 17837, USA., Reeder DM; Department of Biology, Bucknell University, Lewisburg, PA, 17837, USA. dreeder@bucknell.edu.
Jazyk: angličtina
Zdroj: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology [J Comp Physiol B] 2018 Jan; Vol. 188 (1), pp. 163-176. Date of Electronic Publication: 2017 Jun 08.
DOI: 10.1007/s00360-017-1109-2
Abstrakt: The devastating bat fungal disease, white-nose syndrome (WNS), does not appear to affect all species equally. To experimentally determine susceptibility differences between species, we exposed hibernating naïve little brown myotis (Myotis lucifugus) and big brown bats (Eptesicus fuscus) to the fungus that causes WNS, Pseudogymnoascus destructans (Pd). After hibernating under identical conditions, Pd lesions were significantly more prevalent and more severe in little brown myotis. This species difference in pathology correlates with susceptibility to WNS in the wild and suggests that survival is related to different host physiological responses. We observed another fungal infection, associated with neutrophilic inflammation, that was equally present in all bats. This suggests that both species are capable of generating a response to cold tolerant fungi and that Pd may have evolved mechanisms for evading host responses that are effective in at least some bat species. These host-pathogen interactions are likely mediated not just by host physiological responses, but also by host behavior. Pd-exposed big brown bats, the less affected species, spent more time in torpor than did control animals, while little brown myotis did not exhibit this change. This differential thermoregulatory response to Pd infection by big brown bat hosts may allow for a more effective (or less pathological) immune response to tissue invasion.
Databáze: MEDLINE
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