| Autor: |
Mak A; Department of Medicine, National University of Singapore, Singapore, Singapore.; Division of Rheumatology, National University Hospital, Singapore, 119074, Singapore., Thornhill SI; Singapore Immunology Network, A*STAR, Singapore, 138648, Singapore., Lee HY; Singapore Immunology Network, A*STAR, Singapore, 138648, Singapore., Lee B; Singapore Immunology Network, A*STAR, Singapore, 138648, Singapore., Poidinger M; Singapore Immunology Network, A*STAR, Singapore, 138648, Singapore., Connolly JE; Institute of Molecular and Cell Biology, A*STAR, Singapore, 138673, Singapore.; Institute of Biomedical Studies, Baylor University, Waco, TX, 76798, USA., Fairhurst AM; Singapore Immunology Network, A*STAR, Singapore, 138648, Singapore. annamarie_fairhurst@immunol.a-star.edu.sg.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. annamarie_fairhurst@immunol.a-star.edu.sg. |
| Abstrakt: |
The signalling lymphocyte activation molecule (SLAM) family receptors play important roles in modulating immune responses. Previous studies in murine models and patients have suggested an association of the SLAM family (SLAMF) members with the development of autoimmunity, particularly systemic lupus erythematosus (SLE). Since previous investigations on CD244 expression have focussed on NK and T cells, the aim of this study was to evaluate the surface expression of major SLAMF members across monocytes and polymorphonuclear cells in an Asian SLE cohort and explore their potential associations with SLE-related disease activity and autoantibodies. Thirty-nine SLE patients and twenty-nine healthy controls (HC) were evaluated for the expression of CD150, CD84, CD229, CD48, CD244, CD352 and CD319. We determined a significantly lower expression of CD244 on monocytes in SLE patients compared to HC. Furthermore, monocyte CD244 expression was negatively associated with several serum autoantibody titres. Our findings suggest that this molecule plays an important role in immune tolerance mechanisms and should be investigated further. |
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