| Autor: |
Infurnari L; San Raffaele Scientific Institute, Laboratory of Microbiology and Virology, Milan, Italy., Galli L; San Raffaele Scientific Institute, Infectious Diseases Department, Milan, Italy., Bigoloni A; San Raffaele Scientific Institute, Infectious Diseases Department, Milan, Italy., Carbone A; San Raffaele Scientific Institute, Infectious Diseases Department, Milan, Italy., Chiappetta S; San Raffaele Scientific Institute, Infectious Diseases Department, Milan, Italy., Sala A; Saint Michel Centre, Society of Priests of the Sacred Heart of Betharram, Health Pastoral Diocese of Bouar, Bouar, Central African Republic., Ceserani N; San Raffaele Scientific Institute, Infectious Diseases Department, Milan, Italy., Lazzarin A; San Raffaele Scientific Institute, Infectious Diseases Department, Milan, Italy.; Università Vita-Salute San Raffaele, Milan, Italy., Castagna A; San Raffaele Scientific Institute, Infectious Diseases Department, Milan, Italy.; Università Vita-Salute San Raffaele, Milan, Italy., Gaiera/ G; San Raffaele Scientific Institute, Infectious Diseases Department, Milan, Italy. |
| Abstrakt: |
Diagnosis of schistosomiasis in migrants coming from endemic areas can be difficult, especially in asymptomatic subjects. Light-intensity disease, in fact, may be missed due to the low sensitivity of the stool microscopy and serologic testing cannot distinguish between a resolved infection and an active infection in patients who have been infected and treated in the past, because specific antibodies can persist despite cure. We describe a cross-sectional study conducted on 82 migrants tested for Schistosoma mansoni on single blood (anti-schistosome antibodies, total IgE) and urine [point-of-care (POC) circulating-cathodic-antigen (CCA) test] samples. A positive POC-CCA test (active infection) resulted in two untreated patients with a positive serology while all patients (n = 66) with a past infection showed a negative POC-CCA test. POC-CCA urine test in combination with serology may be helpful in rapidly differentiate active from past S. mansoni infection in migrants coming from endemic areas. |
