Primary sclerosing cholangitis associated with severe ulcerative colitis in a young man.

Autor:	Xavier JCC Júnior; Department of Pathology - Faculdade de Medicina - Universidade Estadual Paulista, Botucatu/SP, Brazil., Coelho KIR; Department of Pathology - Faculdade de Medicina - Universidade Estadual Paulista, Botucatu/SP, Brazil., Sassaki LY; Department of Internal Medicine - Faculdade de Medicina - Universidade Estadual Paulista, Botucatu/SP, Brazil., Yamashiro FDS; Department of Internal Medicine - Faculdade de Medicina - Universidade Estadual Paulista, Botucatu/SP, Brazil., Oliveira KCL; Department of Internal Medicine - Faculdade de Medicina - Universidade Estadual Paulista, Botucatu/SP, Brazil., Rodrigues MAM; Department of Pathology - Faculdade de Medicina - Universidade Estadual Paulista, Botucatu/SP, Brazil.
Jazyk:	angličtina
Zdroj:	Autopsy & case reports [Autops Case Rep] 2013 Dec 31; Vol. 3 (4), pp. 37-41. Date of Electronic Publication: 2013 Dec 31 (Print Publication: 2013).
DOI:	10.4322/acr.2013.037
Abstrakt:	Primary sclerosing cholangitis, a chronic progressive cholestatic liver disease, is the most serious hepatobiliary complication of ulcerative colitis (UC). The authors present the case of a severe and intractable form of UC associated with primary sclerosing cholangitis, in which the diagnosis of this hepatobiliary complication was made during the postmortem examination. A 19-year-old man, with an 8-month diagnosis of UC, was non-responsive to any therapeutic approach. He presented at the emergency care unit severely ill and with cachexia, and subsequently died of septic shock. The postmortem examination confirmed the clinical diagnosis of severe UC and disclosed the presence of primary sclerosing cholangitis. Although laboratory tests have shown a typical cholestatic profile with elevated alkaline phosphatase and gamma-glutamyl transferase levels, hepatic dysfunction was related to sepsis. This report highlights how challenging the diagnosis of primary sclerosing cholangitis can be and shows the value of the postmortem examination to add important information to a medical diagnosis. Competing Interests: Conflict of interest: None
Databáze:	MEDLINE
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