Learned control of inter-hemispheric connectivity: Effects on bimanual motor performance.

Autor:	Kajal DS; Institute of Medical Psychology and Behavioral Neurobiology, Tübingen, 72076, Germany.; MEG-Center, University of Tübingen, Tübingen, 72076, Germany.; GTC, Graduate Training Center of Neuroscience, University of Tübingen, Tübingen, 72074, Germany.; CIN, Werner Reichardt Centre for Integrative Neuroscience, University of Tübingen, Tübingen, 72076, Germany., Braun C; MEG-Center, University of Tübingen, Tübingen, 72076, Germany.; CIN, Werner Reichardt Centre for Integrative Neuroscience, University of Tübingen, Tübingen, 72076, Germany.; CIMeC, Center for Mind/Brain Sciences, University of Trento, Rovereto, 38068, Italy.; Department of Psychology and Cognitive Science, University of Trento, Rovereto, 38068, Italy., Mellinger J; Max Planck Institute for Intelligent Systems (Department of Empirical Inference), Spemannstr. 41, Tübingen, 72076, Germany., Sacchet MD; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305-5717, USA., Ruiz S; Institute of Medical Psychology and Behavioral Neurobiology, Tübingen, 72076, Germany.; Departamento de Psiquiatría, Escuela de Medicina, Centro Interdisciplinario de Neurociencias, Pontificia Universidad Catolica de Chile, Santiago, Chile.; Laboratory for Brain-Machine Interfaces and Neuromodulation, Pontificia Universidad Católica de Chile, Santiago, Chile., Fetz E; Department of Physiology and Biophysics, University of Washington, Seattle, WA, 98195-7290, USA., Birbaumer N; Institute of Medical Psychology and Behavioral Neurobiology, Tübingen, 72076, Germany.; Wyss Center for Bio and Neuroengineering, Geneva, 1202, Switzerland.; Ospedale San Camillo IRCCS, Venezia, 30126, Italy., Sitaram R; Departamento de Psiquiatría, Escuela de Medicina, Centro Interdisciplinario de Neurociencias, Pontificia Universidad Catolica de Chile, Santiago, Chile.; Laboratory for Brain-Machine Interfaces and Neuromodulation, Pontificia Universidad Católica de Chile, Santiago, Chile.; Institute for Biological and Medical Engineering, Schools of Engineering, Biology and Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Jazyk:	angličtina
Zdroj:	Human brain mapping [Hum Brain Mapp] 2017 Sep; Vol. 38 (9), pp. 4353-4369. Date of Electronic Publication: 2017 Jun 05.
DOI:	10.1002/hbm.23663
Abstrakt:	Bimanual movements involve the interactions between both primary motor cortices. These interactions are assumed to involve phase-locked oscillatory brain activity referred to as inter-hemispheric functional coupling. So far, inter-hemispheric functional coupling has been investigated as a function of motor performance. These studies report mostly a negative correlation between the performance in motor tasks and the strength of functional coupling. However, correlation might not reflect a causal relationship. To overcome this limitation, we opted for an alternative approach by manipulating the strength of inter-hemispheric functional coupling and assessing bimanual motor performance as a dependent variable. We hypothesize that an increase/decrease of functional coupling deteriorates/facilitates motor performance in an out-of-phase bimanual finger-tapping task. Healthy individuals were trained to volitionally regulate functional coupling in an operant conditioning paradigm using real-time magnetoencephalography neurofeedback. During operant conditioning, two discriminative stimuli were associated with upregulation and downregulation of functional coupling. Effects of training were assessed by comparing motor performance prior to (pre-test) and after the training (post-test). Participants receiving contingent feedback learned to upregulate and downregulate functional coupling. Comparing motor performance, as indexed by the ratio of tapping speed for upregulation versus downregulation trials, no change was found in the control group between pre- and post-test. In contrast, the group receiving contingent feedback evidenced a significant decrease of the ratio implicating lower tapping speed with stronger functional coupling. Results point toward a causal role of inter-hemispheric functional coupling for the performance in bimanual tasks. Hum Brain Mapp 38:4353-4369, 2017. © 2017 Wiley Periodicals, Inc. (© 2017 Wiley Periodicals, Inc.)
Databáze:	MEDLINE
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