Low bone mineral density is associated with breast cancer in postmenopausal women: a case-control study.

Autor: Ferreira Poloni P; a Department of Gynecology and Obstetrics , Botucatu Medical School, Sao Paulo State University - UNESP , Sao Paulo , Brazil., Vespoli HL; a Department of Gynecology and Obstetrics , Botucatu Medical School, Sao Paulo State University - UNESP , Sao Paulo , Brazil., Almeida-Filho BS; a Department of Gynecology and Obstetrics , Botucatu Medical School, Sao Paulo State University - UNESP , Sao Paulo , Brazil., Bueloni-Dias F; a Department of Gynecology and Obstetrics , Botucatu Medical School, Sao Paulo State University - UNESP , Sao Paulo , Brazil., Nahas-Neto J; a Department of Gynecology and Obstetrics , Botucatu Medical School, Sao Paulo State University - UNESP , Sao Paulo , Brazil., Nahas EAP; a Department of Gynecology and Obstetrics , Botucatu Medical School, Sao Paulo State University - UNESP , Sao Paulo , Brazil.
Jazyk: angličtina
Zdroj: Climacteric : the journal of the International Menopause Society [Climacteric] 2017 Oct; Vol. 20 (5), pp. 491-497. Date of Electronic Publication: 2017 Jun 01.
DOI: 10.1080/13697137.2017.1329290
Abstrakt: Objective: To evaluate risk factors for low bone mineral density (BMD) in postmenopausal breast cancer survivors compared with postmenopausal women without breast cancer (controls).
Method: In this study, 112 breast cancer survivors were compared to 224 women (controls). Inclusion criteria were amenorrhea ≥12 months, age 45-75 years, treated for breast cancer, and metastasis-free for at least 5 years. The control group consisted of women without breast cancer, matched by age and menopause status (in a proportion of 1: 2 as sample calculation). The risk factors for low BMD (osteopenia/osteoporosis) were assessed by interview. BMD was measured by dual-energy X-ray absorptiometry in the lumbar spine (L1-L4) and femoral neck. Logistic regression models (odds ratio, OR) were used to identify factors associated with low BMD.
Results: The mean (standard deviation) age of breast cancer survivors was 61.3 (9.7) years, with a mean follow-up of 10.2 (3.9) years. These women had a higher incidence of osteopenia (45.1%) and osteoporosis (22.3%) in the femoral neck than controls (39.3% and 9.0%, respectively) (p = 0.0005). Lumbar spine BMD did not differ between groups (p = 0.332). Univariate analysis adjusted for age and time since menopause revealed that chemotherapy (OR 6.90; 95% confidence interval (CI) 5.57-9.77) was associated with a higher risk of low BMD. Contrarily, regular physical exercise (OR 0.24; 95% CI 0.06-0.98) and a body mass index ≥30 kg/m 2 (OR 0.09; 95% CI 0.02-0.37) reduced the risk among breast cancer survivors.
Conclusion: Postmenopausal breast cancer survivors had a higher incidence of osteopenia and osteoporosis in the femoral neck than women without breast cancer. A history of chemotherapy was a risk factor for low BMD, whereas regular physical activity and high body mass index reduced the risk among breast cancer survivors.
Databáze: MEDLINE
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