Serum enolase-2, high-sensitivity C-reactive protein, and serum cholesterol in smear-positive drug-naïve pulmonary tuberculosis.

Autor: Almani SA; Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan., Shaikh TZ; Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan., Khoharo HK; Faculty of Medicine and Allied Medical Sciences, Isra University, Hyderabad, Sindh, Pakistan., Ujjan I; Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
Jazyk: angličtina
Zdroj: Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences [J Res Med Sci] 2017 Apr 26; Vol. 22, pp. 49. Date of Electronic Publication: 2017 Apr 26 (Print Publication: 2017).
DOI: 10.4103/jrms.JRMS_808_16
Abstrakt: Background: Pulmonary tuberculosis (PTB) is a chronic granulomatous disease caused by Mycobacterium tuberculosis . The present study determined the serum human enolase-2 (ENO-2), high-sensitive C-reactive protein (hs-CRP), and serum cholesterol levels as biological marker of disease activity and treatment response in smear-positive drug-naïve PTB.
Materials and Methods: This case-control study was done in the Department of Medicine, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro/Hyderabad, Sindh, from January 2015 to April 2016. Thirty-five sputum smear-positive drug-naïve PTB patients and thirty controls were studied. MTB culture and drug sensitivity were performed at the Diagnostic and Research Laboratory of LUMHS. Serum ENO-2, hs-CRP, and serum cholesterol were estimated at baseline, 3 rd and 6 th month of antituberculosis (TB) therapy.
Results: Serum ENO-2 and hs-CRP were found raised in PTB compared to controls and showed decrease of 13% and 21.55%, 19.6% and 31.5% at 3 rd and 6 th month, respectively ( P = 0.0001). Serum ENO-2 revealed positive correlation with hs-CRP ( r = 0.734, P = 0.0001), and serum cholesterol revealed negative correlation with ENO-2 and hs-CRP ( r = -0.509, P = 0.0001) and ( r = -0.566, P = 0.0001), respectively.
Conclusion: The present study reports the baseline ENO-2 and hs-CRP were raised, and serum cholesterol was low in smear-positive PTB patients and the ENO-2 and hs-CRP were reduced by anti-TB drug therapy.
Competing Interests: There are no conflicts of interest.
Databáze: MEDLINE
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