| Autor: |
Shapiro BA; Laboratory of Mathematical Biology, National Cancer Institute, Frederick Cancer Research Facility, Maryland 21701., Nussinov R, Lipkin LE, Maizel JV Jr |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 1987 Apr; Vol. 4 (5), pp. 697-706. |
| DOI: |
10.1080/07391102.1987.10507673 |
| Abstrakt: |
An interactive computer system using a dot matrix approach has been developed and used to determine potentially significant features due to distortions in the B-DNA helix as a result of variations of purine and pyrimidine patterns. Sequences were compared using matrices which were generated using the Calladine-Dickerson rules (C.R. Calladine, J. Mol. Biol. 161, 343-352, 1982 and R.E. Dickerson, J. Mol. Biol. 166, 419-441, 1983). Having control over various parameters to enhance different aspects of the visual appearance of these matrices was helpful in discovering patterns that were not known a priori. Specifically, it was found that a pattern of alternating doublets of purines and pyrimidines appear to exist in regulatory regions. This event is shown to be beyond probabilistic expectation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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