Relationships of growth factors, proinflammatory cytokines, and anti-inflammatory cytokines with long-term clinical results of autologous bone marrow mononuclear cell transplantation in STEMI.

Autor: Ryabov VV; Cardiology Research Institute, Tomsk National Research Medical Center, Tomsk, Russian Federation.; Siberian State Medical University, Department of Cardiology at the Faculty of Continuous Medical Education, Tomsk, Russian Federation.; National Research Tomsk State University, Laboratory of Translational Cellular and Molecular Biomedicine, Tomsk, Russian Federation., Kirgizova MA; Cardiology Research Institute, Tomsk National Research Medical Center, Tomsk, Russian Federation., Suslova TE; Cardiology Research Institute, Tomsk National Research Medical Center, Tomsk, Russian Federation.; National Research Tomsk State University, Laboratory of Translational Cellular and Molecular Biomedicine, Tomsk, Russian Federation., Karas SI; Siberian State Medical University, Department of Cardiology at the Faculty of Continuous Medical Education, Tomsk, Russian Federation., Markov VA; Cardiology Research Institute, Tomsk National Research Medical Center, Tomsk, Russian Federation.; Siberian State Medical University, Department of Cardiology at the Faculty of Continuous Medical Education, Tomsk, Russian Federation., Karpov RS; Cardiology Research Institute, Tomsk National Research Medical Center, Tomsk, Russian Federation.; Siberian State Medical University, Department of Cardiology at the Faculty of Continuous Medical Education, Tomsk, Russian Federation.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2017 May 30; Vol. 12 (5), pp. e0176900. Date of Electronic Publication: 2017 May 30 (Print Publication: 2017).
DOI: 10.1371/journal.pone.0176900
Abstrakt: Aim: The aim of the study was to test the hypothesis suggesting that the pre-intervention levels of proinflammatory cytokines, anti-inflammatory cytokines, and angiogenic growth factors predict the long-term clinical results of autologous bone marrow-derived mononuclear cell (ABMMC) transplantation in patients with primary ST elevation myocardial infarction (STEMI).
Methods and Results: From 2003 to 2006, a total of 62 patients with primary STEMI were enrolled in an open randomized study registered under the title ESTABOMA. Patients were randomized into two groups: group 1 included patients treated with percutaneous coronary intervention (PCI) and ABMMC transplantation (n = 28); group 2 comprised patients treated only with PCI (n = 34). Follow-up study was performed 7.96 ± 0.96 years after STEMI and involved physical examination, six-minute walk test, echocardiography, and determination of brain natriuretic peptide (BNP) levels. The total and cardiovascular mortality rates were higher in group 1 compared with group 2: 36% (n = 10) vs. 12% (n = 4) (p = 0.02) and 29% (n = 8) vs. 6% (n = 2) (p = 0.03), respectively. Lower levels of proinflammatory cytokines were observed in group 1 after PCI and ABMMC transplantation. Serum levels of FGF, VEGF, and IL-10, determined before PCI and ABMMC transplantation were prognostically significant long-term indicators of unfavorable course of CAD after STEMI.
Databáze: MEDLINE
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