Effects of hemodialysis on intraneural blood flow in end-stage kidney disease.

Autor: Borire AA; Prince of Wales Clinical School, University of New South Wales, Sydney, Australia., Arnold R; School of Medical Sciences, University of New South Wales, Sydney, Australia., Pussell BA; Prince of Wales Clinical School, University of New South Wales, Sydney, Australia., Kwai NC; Prince of Wales Clinical School, University of New South Wales, Sydney, Australia., Visser LH; Elisabeth-Tweesteden Hospital, Department of Neurology, Tilburg, the Netherlands., Simon NG; St Vincent's Clinical School, University of New South Wales, Sydney, Australia.; Brain and Mind Centre, University of Sydney, Sydney, Australia., Kiernan MC; Brain and Mind Centre, University of Sydney, Sydney, Australia., Krishnan AV; Prince of Wales Clinical School, University of New South Wales, Sydney, Australia.
Jazyk: angličtina
Zdroj: Muscle & nerve [Muscle Nerve] 2018 Feb; Vol. 57 (2), pp. 287-293. Date of Electronic Publication: 2017 Jun 14.
DOI: 10.1002/mus.25704
Abstrakt: Introduction: We quantified intraneural blood flow (INBF) in 18 patients with end-stage kidney disease (ESKD) and examined its relationship with nerve size, neuropathy severity, and nerve excitability parameters.
Methods: Sonographic measurements of the median nerve were performed at the same site before and after hemodialysis. INBF was quantified by analyzing power Doppler sonograms to obtain the vessel score (VSc) and maximum perfusion intensity (MPI). Corresponding median motor nerve excitability studies were performed. Neuropathy severity was assessed using Total Neuropathy Score.
Results: A total of 39% of ESKD patients had detectable INBF compared with none in the control group (P < 0.0001). Patients with detectable INBF had larger nerves and more severe neuropathy (P < 0.01). INBF parameters were significantly reduced after a session of dialysis (VSc: P < 0.01; MPI: P < 0.01). A significant relationship was found between interdialytic change in INBF and changes in nerve excitability.
Conclusions: Increased INBF is a potential marker for neuropathy severity in ESKD patients. Muscle Nerve 57: 287-293, 2018.
(© 2017 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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