Microsporidiosis in Iran: A systematic review and meta-analysis.

Autor:	Ghoyounchi R; Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Ahmadpour E; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Spotin A; Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Mahami-Oskouei M; Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: mahamim@tbzmed.ac.ir., Rezamand A; Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pediatrics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Aminisani N; Department of Statistics and Epidemiology, Faculty of Health Sciences, Tabriz University of Medical Sciences, Tabriz, Iran., Ghojazadeh M; Research Center of Evidence Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Berahmat R; Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Mikaeili-Galeh T; Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Jazyk:	angličtina
Zdroj:	Asian Pacific journal of tropical medicine [Asian Pac J Trop Med] 2017 Apr; Vol. 10 (4), pp. 341-350. Date of Electronic Publication: 2017 Apr 06.
DOI:	10.1016/j.apjtm.2017.03.017
Abstrakt:	Objective: To examine all evidence about Microsporidia infection in vertebrate/invertebrate hosts and Iranian populations distributed in different regions of the country. Methods: All published articles up to December 2015, including descriptive and cross-sectional studies related to the prevalence and genotyping of Microsporidia infection in Iran, was considered in this systematic review. The meta-analysis was done using the random-effects model and Stats Direct statistical software. MEGA 5.05 software and maximum likelihood algorithm with Kimura 2-parameter model were used for phylogenetic analysis. Results: Of the 1152 investigated studies, 33 eligible studies reported a prevalence of Microsporidia infection in vertebrate and invertebrate hosts. According to this systematic review, the overall prevalence rate of Microsporidia infection in immunocompromised patients in Iran was 8.18%. Furthermore, the overall prevalence rate of Microsporidia infection in immunocompromised patients with chronic diarrhoea, patients with non-diarrhoea, gastroenteritis, and patients with CD4 (<200 cells/μL) was 15.4%, 4.1%, 0.5%, and 12.9% respectively. The highest prevalence rate of human and animal Microsporidia was estimated in Kerman (29%) and Khuzestan (26.5%). The overall prevalence rate of Microsporidia infection in honeybees using the random-effects model was 40%. Furthermore, the highest prevalence rate of nosemosis was described in East Azerbaijan (48.2%). The most Microsporidia isolates from immunocompromised patients and pigeons in Iran belonged to genotypes D (n = 16; 50%) and E (n = 6; 20.6%) of Enterocytozoon bieneusi. Conclusions: This study may be the first systematic review and meta-analysis that provides a broad outlook on the prevalence of microsporidiosis in Iran. It is necessary to investigate Microsporidia infection in vertebrate and invertebrate hosts and environmental resources in Iran. (Copyright © 2017 Hainan Medical University. Production and hosting by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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